NAGIOS: RODERIC FUNCIONANDO

Orthokeratinized odontogenic cysts: a Spanish tertiary care center study based on HPV DNA detection

Repositori DSpace/Manakin

IMPORTANT: Aquest repositori està en una versió antiga des del 3/12/2023. La nova instal.lació está en https://roderic.uv.es/

Orthokeratinized odontogenic cysts: a Spanish tertiary care center study based on HPV DNA detection

Mostra el registre parcial de l'element

dc.contributor.author Vera-Sirera, Beatriz
dc.contributor.author Rubio Martinez, Luis
dc.contributor.author Forner Navarro, Leopoldo
dc.contributor.author Vera Sempere, Francisco José
dc.date.accessioned 2018-07-24T06:25:06Z
dc.date.available 2018-07-24T06:25:06Z
dc.date.issued 2018
dc.identifier.citation Vera-Sirera, Beatriz Rubio Martinez, Luis Forner Navarro, Leopoldo Vera Sempere, Francisco José 2018 Orthokeratinized odontogenic cysts: a Spanish tertiary care center study based on HPV DNA detection Head & Face Medicine 14 10 1 6
dc.identifier.uri http://hdl.handle.net/10550/67212
dc.description.abstract The role of human papillomavirus (HPV) in orthokeratinized odontogenic cysts (OOCs) has rarely been studied. The objective is to describe the clinicopathological findings in a series of OOCs from a Spanish population that were investigated in relation to the possible presence of HPV. Methods A clinicopathological retrospective analysis followed by a molecular analysis of 28 high- and low-risk HPV genotypes was performed in OOC samples of patients seen during the last 15-years in a Spanish tertiary care center. Results Of 115 odontogenic cysts with keratinization, 16 cases of OOCs were confirmed and evaluated. OOCs occurred predominantly in the mandible of males (mean age 36.06 ± 13.16 years). Swelling of the jaw followed by pain were the most common clinical symptoms, and 56.5% of the OOC cases were associated with an unerupted tooth. After a mean post-cystectomy follow-up of 3.8 years, only one recurrent case was observed, resulting in a verrucous cystic lesion that was considered premalignant after immunohistological examination. DNA extraction was successful from 14 of the 16 OOC cases. None of the primary OCCs or the single recurrent OOC were positive for HPV in the molecular analysis. Conclusions OOCs show a very limited potential for recurrence. Our results suggest that neither high- or low-risk HPV subtypes are likely to play a role in the etiology or neoplastic transformation of OOC, at least in the Spanish population.
dc.language.iso eng
dc.relation.ispartof Head & Face Medicine, 2018, vol. 14, num. 10, p. 1-6
dc.subject Dents Malalties
dc.title Orthokeratinized odontogenic cysts: a Spanish tertiary care center study based on HPV DNA detection
dc.type journal article es_ES
dc.date.updated 2018-07-24T06:25:07Z
dc.identifier.doi 10.1186/s13005-018-0167-3
dc.identifier.idgrec 126480
dc.rights.accessRights open access es_ES

Visualització       (797.6Kb)

Aquest element apareix en la col·lecció o col·leccions següent(s)

Mostra el registre parcial de l'element

Cerca a RODERIC

Cerca avançada

Visualitza

Estadístiques