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Cancer and central nervous system disorders: protocol for an umbrella review of systematic reviews and updated meta-analyses of observational studies

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Cancer and central nervous system disorders: protocol for an umbrella review of systematic reviews and updated meta-analyses of observational studies

dc.contributor.author	Catalá López, Ferrán
dc.contributor.author	Hutton, Brian
dc.contributor.author	Driver, J.A.
dc.contributor.author	Page, Matthew J.
dc.contributor.author	Ridao, Manuel
dc.contributor.author	Valderas, José María
dc.contributor.author	Alonso Arroyo, Adolfo
dc.contributor.author	Forés Martos, Jaume
dc.contributor.author	Martínez, S.
dc.contributor.author	Gènova Maleras, Ricard
dc.contributor.author	Macías Saint-Gerons, Diego
dc.contributor.author	Crespo Facorro, Benedicto
dc.contributor.author	Vieta, Eduard
dc.contributor.author	Valencia, Alfonso
dc.contributor.author	Tabarés Seisdedos, Rafael
dc.date.accessioned	2018-09-03T17:51:14Z
dc.date.available	2018-09-03T17:51:14Z
dc.date.issued	2017
dc.identifier.citation	Catalá López, Ferrán Hutton, Brian Driver, J.A. Page, Matthew J. Ridao, Manuel Valderas, José María Alonso Arroyo, Adolfo Forés Martos, Jaume Martínez, S. Gènova Maleras, Ricard Macías Saint Gerons, Diego Crespo Facorro, Benedicto Vieta, Eduard Valencia, Alfonso Tabarés Seisdedos, Rafael 2017 Cancer and central nervous system disorders: protocol for an umbrella review of systematic reviews and updated meta-analyses of observational studies Systematic Reviews 6 69 76
dc.identifier.uri	http://hdl.handle.net/10550/67384
dc.description.abstract	BACKGROUND: The objective of this study will be to synthesize the epidemiological evidence and evaluate the validity of the associations between central nervous system disorders and the risk of developing or dying from cancer. METHODS/DESIGN: We will perform an umbrella review of systematic reviews and conduct updated meta-analyses of observational studies (cohort and case-control) investigating the association between central nervous system disorders and the risk of developing or dying from any cancer or specific types of cancer. Searches involving PubMed/MEDLINE, EMBASE, SCOPUS and Web of Science will be used to identify systematic reviews and meta-analyses of observational studies. In addition, online databases will be checked for observational studies published outside the time frames of previous reviews. Eligible central nervous system disorders will be Alzheimer's disease, anorexia nervosa, amyotrophic lateral sclerosis, autism spectrum disorders, bipolar disorder, depression, Down's syndrome, epilepsy, Huntington's disease, multiple sclerosis, Parkinson's disease and schizophrenia. The primary outcomes will be cancer incidence and cancer mortality in association with a central nervous system disorder. Secondary outcome measures will be site-specific cancer incidence and mortality, respectively. Two reviewers will independently screen references identified by the literature search, as well as potentially relevant full-text articles. Data will be abstracted, and study quality/risk of bias will be appraised by two reviewers independently. Conflicts at all levels of screening and abstraction will be resolved through discussion. Random-effects meta-analyses of primary observational studies will be conducted where appropriate. Parameters for exploring statistical heterogeneity are pre-specified. The World Cancer Research Fund (WCRF)/American Institute for Cancer Research (AICR) criteria and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach will be used for determining the quality of evidence for cancer outcomes. DISCUSSION: Our study will establish the extent of the epidemiological evidence underlying the associations between central nervous system disorders and cancer and will provide a rigorous and updated synthesis of a range of important site-specific cancer outcomes. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42016052762.
dc.language.iso	eng
dc.relation.ispartof	Systematic Reviews, 2017, num. 6, p. 69-76
dc.subject	Càncer
dc.subject	Sistema nerviós central Malalties
dc.subject	Anorèxia nerviosa
dc.subject	Autisme
dc.subject	Esquizofrènia
dc.title	Cancer and central nervous system disorders: protocol for an umbrella review of systematic reviews and updated meta-analyses of observational studies
dc.type	journal article	es_ES
dc.date.updated	2018-09-03T17:51:15Z
dc.identifier.doi	10.1186/s13643-017-0466-y
dc.identifier.idgrec	117657
dc.rights.accessRights	open access	es_ES