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Risk of mortality among children, adolescents, and adults with autism spectrum disorder or attention déficit hyperactivity disorder and their first-degree relatives : a protocol for a systematic review and meta-analysis of observational studies

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Risk of mortality among children, adolescents, and adults with autism spectrum disorder or attention déficit hyperactivity disorder and their first-degree relatives : a protocol for a systematic review and meta-analysis of observational studies

dc.contributor.author	Catalá López, Ferrán
dc.contributor.author	Hutton, Brian
dc.contributor.author	Page, Matthew J.
dc.contributor.author	Ridao, Manuel
dc.contributor.author	Driver, J.A.
dc.contributor.author	Alonso Arroyo, Adolfo
dc.contributor.author	Forés Martos, Jaume
dc.contributor.author	Macías Saint-Gerons, Diego
dc.contributor.author	Vieta, Eduard
dc.contributor.author	Valencia, Alfonso
dc.contributor.author	Tabarés Seisdedos, Rafael
dc.date.accessioned	2018-09-04T17:10:26Z
dc.date.available	2018-09-04T17:10:26Z
dc.date.issued	2017
dc.identifier.citation	Catalá López, Ferrán Hutton, Brian Page, Matthew J. Ridao, Manuel Driver, J.A. Alonso Arroyo, Adolfo Forés Martos, Jaume Macías Saint Gerons, Diego Vieta, Eduard Valencia, Alfonso Tabarés Seisdedos, Rafael 2017 Risk of mortality among children, adolescents, and adults with autism spectrum disorder or attention déficit hyperactivity disorder and their first-degree relatives : a protocol for a systematic review and meta-analysis of observational studies Systematic Reviews 6 189
dc.identifier.uri	http://hdl.handle.net/10550/67397
dc.description.abstract	Background: Autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) are childhood onset neurodevelopmental disorders that may persist into adulthood. ASD and ADHD tend to run in families and may have a significant negative impact on the health and longevity of those with the disorder and their relatives. The aim of this study will be to analyze the risk of mortality among children, adolescents, and adults with ASD or ADHD and their first-degree relatives. Methods/design: We will conduct a systematic review and meta-analysis of observational studies. Searches of PubMed/MEDLINE, EMBASE, PsycINFO, SCOPUS, and ISI Web of Science will be used to identify epidemiological studies. Eligible studies will be observational studies reporting study-specific data for all-cause mortality or cause-specific mortality in children, adolescents, or adults with ASD or ADHD and/or their first-degree relatives. Cohort studies and case-control studies will be included. The primary outcome will be all-cause mortality. The secondary outcome will be cause-specific mortality. Two reviewers will independently screen references identified by the literature search, as well as potentially relevant full-text articles. Data will be abstracted, and study risk of bias/methodological quality will be appraised by two reviewers independently. The methodological quality of epidemiological studies will be appraised using the Newcastle-Ottawa Scale (NOS). Conflicts at all levels of screening and abstraction will be resolved through discussion. Random-effects meta-analyses of primary studies will be conducted where appropriate. Subgroup analyses for exploring statistical heterogeneity, if feasible, will include gender, age group, ethnicity, comorbidities, classification of cause of death, and relevant study characteristics. Discussion: Our study will establish the extent of the epidemiological evidence underlying the risk of mortality among children, adolescents, and adults with ASD or ADHD and their first-degree relatives. We anticipate that our findings will be of interest to patients, their families, caregivers, healthcare professionals, scientists, and policy makers. Implications for future epidemiological research will be discussed. Systematic review registration: PROSPERO CRD42017059955. © 2017 The Author(s).
dc.language.iso	eng
dc.relation.ispartof	Systematic Reviews, 2017, num. 6, p. 189
dc.subject	Mortalitat
dc.subject	Adults
dc.subject	Adolescents
dc.subject	Infants
dc.subject	Autisme
dc.subject	Trastorns de l'atenció
dc.subject	Bibliometria
dc.title	Risk of mortality among children, adolescents, and adults with autism spectrum disorder or attention déficit hyperactivity disorder and their first-degree relatives : a protocol for a systematic review and meta-analysis of observational studies
dc.type	journal article	es_ES
dc.date.updated	2018-09-04T17:10:26Z
dc.identifier.doi	10.1186/s13643-017-0581-9
dc.identifier.idgrec	121337
dc.rights.accessRights	open access	es_ES