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Relevance of secretor status genotype and microbiota composition in susceptibility to rotavirus and norovirus infections in humans

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Relevance of secretor status genotype and microbiota composition in susceptibility to rotavirus and norovirus infections in humans

dc.contributor.author	Rodríguez Díaz, Jesús
dc.contributor.author	García Mantrana, Izaskun
dc.contributor.author	Vila Vicent, Susana
dc.contributor.author	Gozalbo Rovira, Roberto Vicente
dc.contributor.author	Buesa Gómez, Javier
dc.contributor.author	Monedero García, Vicente
dc.contributor.author	Collado, María Carmen
dc.date.accessioned	2018-11-05T14:23:17Z
dc.date.available	2018-11-05T14:23:17Z
dc.date.issued	2017
dc.identifier.citation	Rodríguez Díaz, Jesús García Mantrana, Izaskun Vila Vicent, Susana Gozalbo Rovira, Roberto Vicente Buesa Gómez, Javier Monedero García, Vicente Collado, María Carmen 2017 Relevance of secretor status genotype and microbiota composition in susceptibility to rotavirus and norovirus infections in humans Scientific Reports 7 45559 45559-1 45559-10
dc.identifier.uri	http://hdl.handle.net/10550/67853
dc.description.abstract	Host genetic factors, such as histo-blood group antigens (HBGAs), are associated with susceptibility to norovirus (NoV) and rotavirus (RV) infections. Recent advances point to the gut microbiome as a key player necessary for a viral pathogen to cause infection. In vitro NoV attachment to host cells and resulting infections have been linked to interactions with certain bacterial types in the gut microbiota. We investigated the relationship between host genotype, gut microbiota, and viral infections. Saliva and fecal samples from 35 adult volunteers were analysed for secretor status genotype, the gut microbiota composition by 16S rRNA gene sequencing, and salivary IgA titers to NoV and RV. Higher levels of IgA against NoV and RV were related to secretor-positive status. No significant differences were found between the FUT2 genotype groups, although the multivariate analysis showed a significant impact of host genotype on specific viral susceptibilities in the microbiome composition. A specific link was found between the abundance of certain bacterial groups, such as Faecalibacterium and Ruminococcus spp., and lower IgA titers against NoV and RV. As a conclusion, we can state that there is a link between host genetics, gut microbiota, and susceptibility to viral infections in humans.
dc.language.iso	eng
dc.relation.ispartof	Scientific Reports, 2017, vol. 7, num. 45559, p. 45559-1-45559-10
dc.subject	Microbiologia
dc.subject	Virus
dc.title	Relevance of secretor status genotype and microbiota composition in susceptibility to rotavirus and norovirus infections in humans
dc.type	journal article	es_ES
dc.date.updated	2018-11-05T14:23:17Z
dc.identifier.doi	10.1038/srep45559
dc.identifier.idgrec	118660
dc.rights.accessRights	open access	es_ES