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Survival study of leukoplakia malignant transformation in a region of northern Spain

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Survival study of leukoplakia malignant transformation in a region of northern Spain

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dc.contributor.author Gándara Vila, Pilar es
dc.contributor.author Pérez-Sayáns, Mario es
dc.contributor.author Suárez Peñaranda, José Manuel es
dc.contributor.author Gallas Torreira, M. Mercedes es
dc.contributor.author Somoza Martín, José Manuel es
dc.contributor.author Reboiras López, Dolores es
dc.contributor.author Blanco Carrión, Andrés es
dc.contributor.author García García, Abel es
dc.date.accessioned 2018-11-27T08:34:28Z
dc.date.available 2018-11-27T08:34:28Z
dc.date.issued 2018 es
dc.identifier.citation Gándara Vila, Pilar ; Pérez-Sayáns, Mario ; Suárez Peñaranda, José Manuel ; Gallas Torreira, M. Mercedes ; Somoza Martín, José Manuel ; Reboiras López, Dolores ; Blanco Carrión, Andrés ; García García, Abel. Survival study of leukoplakia malignant transformation in a region of northern Spain. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 23 4 2018: 6- es
dc.identifier.uri http://hdl.handle.net/10550/68040
dc.description.abstract Oral leukoplakia is the most common potentially malignant disorder (PMD) of the oral cavity. The objectives of this study are to determine the clinicopathologic features in a group of patients with oral leukoplakia of Northern Spain (Galicia), determining the factors associated to clinical risk and analyzing the malignant transformation of these patients. We included 85 patients. We recorded sex and age, habits like alcohol and tobacco, size, clinical appearance, site, number of lesions, and presence or absence of dysplasia. We assess the association between risk factors and transformation and developed a logistic regression analysis. Finally we used the Kaplan-Meier and log-rank test for the survival analysis. 7 patients (8.2%) had malignant transformation. The mean follow-up of the patients was 4.13 years versus 5.58 years of those who developed carcinoma. Only location and initial dysplasia have a statistically significant relationship with malignant transformation, but when applied the long rank test only the presence of dysplasia remains statistically significant(P<0,026). Oral Cancer Free Survival was 81.9% (0.150) at 11 years for the group without dysplasia. We found that the presence of dysplasia is the only risk factor that is statistically related to the development of a carcinoma. es
dc.title Survival study of leukoplakia malignant transformation in a region of northern Spain es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.22326 es
dc.type.hasVersion VoR es_ES

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