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Epstein-Barr virus is not detected in mucosal lichen planus

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Epstein-Barr virus is not detected in mucosal lichen planus

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dc.contributor.author Danielsson, Karin es
dc.contributor.author Nylander, Elisabet es
dc.contributor.author Sjöström, Mats es
dc.contributor.author Ebrahimi, Majid es
dc.date.accessioned 2018-11-27T08:34:50Z
dc.date.available 2018-11-27T08:34:50Z
dc.date.issued 2018 es
dc.identifier.citation Danielsson, Karin ; Nylander, Elisabet ; Sjöström, Mats ; Ebrahimi, Majid. Epstein-Barr virus is not detected in mucosal lichen planus. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 23 5 2018: 1- es
dc.identifier.uri http://hdl.handle.net/10550/68053
dc.description.abstract Lichen planus (LP) is a chronic inflammatory, immunological, mucocutaneous disease can affect skin, genital and oral mucosa. Oral lichen planus (OLP) is the most common noninfectious, chronic inflammatory oral disease affecting 1-2% of the general adult population. World Health Organization (WHO) classifies OLP as a potentially malignant disorder. Epstein Barr virus or human herpesvirus-4, is a member of the herpes virus family and one of the most ubiquitous viruses known to human, infecting approximately 90% of the world?s adult population. The virus often infects B lymphocytes resulting in a wide spectrum of mucocutaneous and systemic diseases, ranging from mild lesions to aggressive malignancies. The aim of this study was to investigate expression of the EBV encoded RNAs EBER1 and EBER2 in oral and genital lichen planus and compare results with normal tissues in situ hybridization which is considered the golden standard for detection of EBER. A total of 68 biopsies, 25 oral LP, 26 genital LP, 10 oral controls and finally 7 genital controls were analysed using situ hybridization. All samples had RNA as shown by the control slide, whereas no case contained neither EBER1 nor EBER2. Based on results from our study EBV is not involved in aetiology of lichen planus. es
dc.title Epstein-Barr virus is not detected in mucosal lichen planus es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.22617 es
dc.type.hasVersion VoR es_ES

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