Sintering process is responsible for the strength of zirconia restoration. This study evaluated the effect of different sintering temperatures and sintered-holding times on flexural strength of translucency monolithic zirconia. One hundred and thirty five zirconia bar specimens (width-length-thickness = 10×20×1.5 mm) were prepared from yttria-stabilized tetragonal zirconia polycrystalline (Y-TZP) ceramic and randomly divided into nine groups to be sintered at different temperatures [decreasing- (SD, 1350°C), regular- (SR, 1450°C), and increasing- (SI, 1550°C) sintering temperature] and different sintered-holding times [shortening- (HS, 60 min), regular- (HR, 120 min), and prolonged- (HP, 180 min) sintered-holding time]. Flexural strength was determined using three-point bending test in a universal testing machine at 1 mm/min crosshead speed. An analysis of variance (ANOVA) and Tukey?s multiple comparisons were used to determine for statistically significant difference of flexural strength (?=0.05). Weibull analysis was applied for survival probability, Weibull modulus (m), and characteristics strength (?o) of the flexural strength. The crystal sizes were microscopically examined using scanning electron microscope (SEM). The phase composition of zirconia was determined using X-ray diffraction (XRD). The mean±sd (MPa), m, and ?o of flexural strength were 1080.25±217.19, 5.54, and 1167.53 for SDHS, 1243.41±233.17, 5.19, and 1352.30 for SDHR, 1298.92±235.68, 6.24, and 1394.79 for SDHP, 1303.34±171.87, 8.40, and 1377.90 for SRHS, 1331.73±278.84, 5.31, and 1444.50 for SRHR, 1348.13±283.35, 5.32, and 1460.68 for SRHP, 1458.45±289.19, 4.51, and 1604.41 for SIHS 1581.34±190.56, 8.20, and 1675.21 for SIHR and, 1604.10±139.52, 12.57, and 1667.90 for SIHP. The flexural strength was significantly affected by altering sintering temperatures and holding times (p<0.05). Enlarging grain size and increasing t?m phase shifting related with raising temperatures and times. Increasing sintering temperature and prolonged sintered-holding time lead to enhancing flexural strength of translucency monolithic zirconia, and are suggested for sintering process to achieve durable restoration.