The aim of this report is to analyze the clinical performance of 20 full-arch implant-supported titanium frameworks using CAD/CAM (Computer-Aided Design and Computer-Aided Manufacturing) technology. One hundred and four implants were placed in 15 patients using a one-stage protocol. After planning the location of all implants via 3-dimensional software (NobleClinician), 4-8 implants were placed in each edentulous arch based on anatomical measurements. Twenty edentulous arches were treated with full arch implant-supported fixed dental prostheses utilizing CAD/CAM milled titanium frameworks . All patients were followed up for 48±4 months. Clinical performance of the implants and restorations were evaluated for implant/prosthesis survival, framework fit, marginal bone levels, and maintenance requirements. One implant was lost during the follow up period, giving an implant survival rate of 99.1%. The average distance from the implant platform to first bone-implant contact was 1.1±0.2 mm from the time of metal-framework try-in to the time of the last recall appointment. None of the prostheses needed a replacement, indicating the prosthesis success rate was 100%. Sixteen occlusal adjustments and 5 broken denture teeth were repaired chairside during the study period. The results of this retrospective clinical report suggest that CAD/CAM milled titanium frameworks using the software and scanner presented in this study fit accurately and can be a viable treatment option to restore edentulous arches.