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Peptide Metal-Organic Frameworks for Enantioselective Separation of Chiral Drugs

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Peptide Metal-Organic Frameworks for Enantioselective Separation of Chiral Drugs

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dc.contributor.author	Navarro-Sánchez, José
dc.contributor.author	Argente García, Ana Isabel
dc.contributor.author	Moliner Martínez, Yolanda
dc.contributor.author	Roca Sanjuán, Daniel
dc.contributor.author	Antypov, Dmytro
dc.contributor.author	Campíns Falcó, Pilar
dc.contributor.author	Rosseinsky, Matthew J.
dc.contributor.author	Martí Gastaldo, Carlos
dc.date.accessioned	2019-01-11T14:16:40Z
dc.date.available	2019-01-11T14:16:40Z
dc.date.issued	2017
dc.identifier.citation	Navarro-Sánchez, José Argente García, Ana Isabel Moliner Martínez, Yolanda Roca Sanjuán, Daniel Antypov, Dmytro Campíns Falcó, Pilar Rosseinsky, Matthew J. Martí Gastaldo, Carlos 2017 Peptide Metal-Organic Frameworks for Enantioselective Separation of Chiral Drugs Journal of the American Chemical Society 139 12 4294 4297
dc.identifier.uri	http://hdl.handle.net/10550/68465
dc.description.abstract	We report the ability of a chiral Cu(II) 3D MOF based on the tripeptide Gly-L-His-Gly (GHG) for the enantioselective separation of metamphetamine and ephedrine. Monte Carlo simulations suggest that chiral recognition is linked to preferential binding of one of the enantiomers as result of either stronger or additional H-bonds with the framework that lead to energetically more stable diastereomeric adducts. Solid phase extraction (SPE) of a racemic mixture by using Cu(GHG) as extractive phase permits isolating more than 50% of the (+)-ephedrine enantiomer as target compound in only four minutes. To the best of our knowledge, this represents the first example of a MOF capable of separating chiral polar drugs.
dc.language.iso	eng
dc.relation.ispartof	Journal of the American Chemical Society, 2017, vol. 139, num. 12, p. 4294-4297
dc.subject	Pèptids
dc.subject	Química
dc.title	Peptide Metal-Organic Frameworks for Enantioselective Separation of Chiral Drugs
dc.type	journal article	es_ES
dc.date.updated	2019-01-11T14:16:41Z
dc.identifier.doi	10.1021/jacs.7b00280
dc.identifier.idgrec	117899
dc.rights.accessRights	open access	es_ES