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CX3CR1/CX3CL1 AXIS mediates platelet-leukocyte adhesion to arterial endothelium in younger patients with a history of idiopathic deep vein thrombosis

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CX3CR1/CX3CL1 AXIS mediates platelet-leukocyte adhesion to arterial endothelium in younger patients with a history of idiopathic deep vein thrombosis

dc.contributor.author	Furio, Elena
dc.contributor.author	García-Fuster, María José
dc.contributor.author	Redón i Más, Josep
dc.contributor.author	Marques, Patrice
dc.contributor.author	Ortega, Rebeca
dc.contributor.author	Sanz Ferrando, María Jesús
dc.contributor.author	Piqueras Ruiz, Laura
dc.date.accessioned	2019-02-07T08:34:48Z
dc.date.available	2019-02-07T08:34:48Z
dc.date.issued	2018
dc.identifier.citation	Furio, Elena García-Fuster, María José Redón i Más, Josep Marques, Patrice Ortega, Rebeca Sanz, María Jesus Piqueras, Laura 2018 CX3CR1/CX3CL1 AXIS mediates platelet-leukocyte adhesion to arterial endothelium in younger patients with a history of idiopathic deep vein thrombosis. Thrombosis and Haemostasis 118 3 562 571
dc.identifier.uri	http://hdl.handle.net/10550/68887
dc.description.abstract	Mechanisms linking deep vein thrombosis (DVT) and subclinical atherosclerosis and risk of cardiovascular events are poorly understood. The aim of this study was to investigate the potential impact of CX3CR1/CX3CL1 axis in DVT-associated endothelial dysfunction. The study included 22 patients (age: 37.5 ± 8.2 years) with a history of idiopathic DVT and without known cardiovascular risk factors and 23 aged-matched control subjects (age: 34 ± 7.8 years). Flow cytometry was used to evaluate peripheral markers of platelet activation, leukocyte immunophenotypes and CX3CR1/CX3CL1 expression in both groups. A flow chamber assay was employed to measure leukocyte arrest under dynamic conditions. Platelet activation and the percentage of circulating CX3CR1-expressing platelets, CX3CR1-expressing platelet-bound monocytes and CD8+ lymphocytes were higher in patients with DVT than in controls. Additionally, patients with DVT had increased plasma levels of CX3CL1, soluble P-selectin and platelet factor 4/CXCL4. Interestingly, this correlated with enhanced platelet-leukocyte interaction and leukocyte adhesion to TNFα-stimulated arterial endothelial cells, which was partly dependent on endothelial CX3CL1 upregulation and increased CX3CR1 expression on platelets, monocytes and lymphocytes. In conclusion, increased CX3CR1 expression on circulating platelets may constitute a prognostic marker for long-term adverse cardiovascular events in patients with DVT. Blockade of CX3CL1/CX3CR1 axis may represent a new therapeutic strategy for the prevention of cardiovascular comorbidities associated with DVT.
dc.language.iso	cat
dc.relation.ispartof	Thrombosis and Haemostasis, 2018, vol. 118, num. 3, p. 562-571
dc.subject	Sistema cardiovascular
dc.subject	Sistema cardiovascular
dc.title	CX3CR1/CX3CL1 AXIS mediates platelet-leukocyte adhesion to arterial endothelium in younger patients with a history of idiopathic deep vein thrombosis
dc.type	journal article	es_ES
dc.date.updated	2019-02-07T08:34:49Z
dc.identifier.doi	10.1055/s-0038-1629897
dc.identifier.idgrec	123997
dc.rights.accessRights	open access	es_ES