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LDL particle size and composition and incident cardiovascular disease in a South-European population: The Hortega-Liposcale Follow-up Study.

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LDL particle size and composition and incident cardiovascular disease in a South-European population: The Hortega-Liposcale Follow-up Study.

dc.contributor.author	Pichler, Gernot Helmut
dc.contributor.author	Amigo, N.
dc.contributor.author	Téllez-Plaza, María
dc.contributor.author	Pardo-Cea, M.A.
dc.contributor.author	Dominguez Lucas, Alejandro
dc.contributor.author	González Marrachelli, Vannina Elena
dc.contributor.author	Monleon, D.
dc.contributor.author	Martin Escudero, Juan Carlos
dc.contributor.author	Ascaso Gimilio, Juan Francisco
dc.contributor.author	Chaves Martínez, Felipe Javier
dc.contributor.author	Carmena Rodriguez, Rafael
dc.contributor.author	Redón i Más, Josep
dc.date.accessioned	2019-02-07T12:23:12Z
dc.date.available	2019-04-07T04:45:05Z
dc.date.issued	2018
dc.identifier.citation	Pichler, Gernot Helmut Amigo, N. Tellez-Plaza, Maria Pardo-Cea, M.A. Dominguez Lucas, Alejandro Gonzalez Marrachelli, Vannina Elena Monleon, D. Martin Escudero, Juan Carlos Ascaso Gimilio, Juan Francisco Chaves Martinez, Felipe Javier Carmena Rodriguez, Rafael Redón i Más, Josep 2018 LDL particle size and composition and incident cardiovascular disease in a South-European population: The Hortega-Liposcale Follow-up Study. International Journal of Cardiology 264 172 178
dc.identifier.uri	http://hdl.handle.net/10550/68895
dc.description.abstract	The association of low-density lipoprotein (LDL) particle composition with cardiovascular risk has not been explored before. The aim was to evaluate the relationship between baseline LDL particle size and composition (proportions of large, medium and small LDL particles over their sum expressed as small-LDL %, medium-LDL % and large-LDL %) and incident cardiovascular disease in a population-based study. Methods: Direct measurement of LDL particles was performed using a two-dimensional NMR-technique (Liposcale®). LDL cholesterol was assessed using both standard photometrical methods and the Liposcale® technique in a representative sample of 1162 adult men and women from Spain. Results: The geometric mean of total LDL particle concentration in the study sample was 827.2 mg/dL (95% CI 814.7, 839.8). During a mean follow-up of 12.4 ± 3.3 years, a total of 159 events occurred. Medium LDL particles were positively associated with all cardiovascular disease, coronary heart disease (CHD) and stroke after adjustment for traditional risk factors and treatment. Regarding LDL particle composition, the multivariable adjusted hazard ratios for CHD for a 5% increase in medium and small LDL % by a corresponding decrease of large LDL % were 1.93 (1.55, 2.39) and 1.41 (1.14, 1.74), respectively. Conclusions: Medium LDL particles were associated with incident cardiovascular disease. LDL particles showed the strongest association with cardiovascular events when the particle composition, rather than the total concentration, was investigated. A change in baseline composition of LDL particles from large to medium and small LDL particles was associated with an increased cardiovascular risk, especially for CHD.
dc.language.iso	eng
dc.relation.ispartof	International Journal of Cardiology, 2018, vol. 264, p. 172-178
dc.subject	Cor Malalties
dc.title	LDL particle size and composition and incident cardiovascular disease in a South-European population: The Hortega-Liposcale Follow-up Study.
dc.type	journal article	es_ES
dc.date.updated	2019-02-07T12:23:12Z
dc.identifier.doi	10.1016/j.ijcard.2018.03.128.
dc.identifier.idgrec	124977
dc.embargo.terms	2 months
dc.rights.accessRights	open access	es_ES