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Preemptive analgesia-related gene and protein expression in third molar surgeries under non steroidal anti-inflammatory drug protocols : A PROSPERO-registered systematic review of clinical studies

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Preemptive analgesia-related gene and protein expression in third molar surgeries under non steroidal anti-inflammatory drug protocols : A PROSPERO-registered systematic review of clinical studies

dc.contributor.author	Medeiros Albuquerque, Assis Filipe	es
dc.contributor.author	Sampaio-Melo, Carline-Maria	es
dc.contributor.author	Soares, Eduardo Costa Studart	es
dc.contributor.author	Rodrigues-Ribeiro, Thyciana	es
dc.contributor.author	Sá Roriz Fonteles, Cristiane	es
dc.contributor.author	Alves Pereira, Karuza Maria	es
dc.contributor.author	Ferreira-Barbosa, Daniel-Almeida	es
dc.contributor.author	Silva, Paulo-Goberlânio-de Barros	es
dc.contributor.author	Costa, Fabio Wildson Gurgel	es
dc.date.accessioned	2019-02-14T08:20:57Z
dc.date.available	2019-02-14T08:20:57Z
dc.date.issued	2018	es
dc.identifier.citation	Medeiros Albuquerque, Assis Filipe ; Sampaio-Melo, Carline-Maria ; Soares, Eduardo Costa Studart ; Rodrigues-Ribeiro, Thyciana ; Sá Roriz Fonteles, Cristiane ; Alves Pereira, Karuza Maria ; Ferreira-Barbosa, Daniel-Almeida ; Silva, Paulo-Goberlânio-de Barros ; Costa, Fabio Wildson Gurgel. Preemptive analgesia-related gene and protein expression in third molar surgeries under non steroidal anti-inflammatory drug protocols : A PROSPERO-registered systematic review of clinical studies. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 23 6 2018: 12-	es
dc.identifier.uri	http://hdl.handle.net/10550/68961
dc.description.abstract	This study aimed to review translational studies focusing on third molar removal surgeries through a systematic analytical approach. A PROSPERO-registered systematic review (CRD42017060455) was conducted following the PRISMA statement to summarize current knowledge on gene expression in third molar surgeries. A search was performed in PubMed?s Medline and Scopus databases, without date or language restrictions, using the logical expression {[(Third molar) OR (preemptive) OR (cyclooxygenase inhibitors) OR (acute inflammation) AND (gene expression)]}. All studies included in the analysis evaluated gene expression in a third molar extraction model, using the preemptive analgesia methodology in seven investigations. The sample analyzed was obtained from gingival tissue biopsy (n=4), blood (n=1), transudate (n=1) and gingival tissue biopsy/transudate (n=1). There were differences with respect to evaluated genes, drug protocol, sample studied, and method for evaluating gene expression. Third molar surgeries were found to be associated with different COX-related gene expression patterns. Although inflammatory events following the surgical procedure are associated with COX isoforms, data from preemptive analgesia studies are scarce, especially from studies correlating gene expression and clinical parameters. In the future, from a clinical perspective, identifying the molecular targets of a drug based on individual gene expression may be helpful to delineate specific third molar, surgery-related, preemptive analgesia protocols.	es
dc.title	Preemptive analgesia-related gene and protein expression in third molar surgeries under non steroidal anti-inflammatory drug protocols : A PROSPERO-registered systematic review of clinical studies	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO::CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.22576	es
dc.type.hasVersion	VoR	es_ES