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Staging, neurocognition and social functioning in bipolar disorder.

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Staging, neurocognition and social functioning in bipolar disorder.

dc.contributor.author	Tatay Manteiga, Amparo
dc.contributor.author	Correa Ghisays, Patricia María
dc.contributor.author	Cauli, Omar
dc.contributor.author	Kapczinski, FP
dc.contributor.author	Tabarés Seisdedos, Rafael
dc.contributor.author	Balanzá Martínez, Vicent
dc.date.accessioned	2019-02-26T12:08:08Z
dc.date.available	2019-02-26T12:08:08Z
dc.date.issued	2018
dc.identifier.citation	Tatay Manteiga, Amparo A Correa Ghisays, Patricia María Cauli, Omar Kapczinski, FP Tabarés Seisdedos, Rafael Balanzá Martínez, Vicent 2018 Staging, neurocognition and social functioning in bipolar disorder. Frontiers In Psychiatry 9 709
dc.identifier.uri	http://hdl.handle.net/10550/69185
dc.description.abstract	Introduction: Bipolar disorder (BD) is associated with significant neurocognitive and functional impairment, which may progress across stages. The 'latent stage' of BD remains understudied. This cross-sectional study assessed staging, neurocognition and social functioning among BD patients and their healthy siblings. Methods: Four groups were included: euthymic type I BD patients in the early (n = 25) and late (n = 23) stages, their healthy siblings (latent stage; n = 23) and healthy controls (n = 21). All 92 subjects underwent a comprehensive neuropsychological battery of processing speed, verbal learning/memory, visual memory, working memory, verbal fluency, executive cognition, and motor speed. Social functioning was assessed using the FAST scale. Results: Siblings' social functioning was identical to that of controls, and significantly better than both early- (p < 0.005) and late- (p < 0.001) stage patients. Although all patients were strictly euthymic, those at late stages had a significantly worse social functioning than early-stage patients (p < 0.001). Compared to controls, increasingly greater neurocognitive dysfunction was observed across stages of BD (F = 1.59; p = 0.005). Healthy siblings' performance lied between those of controls and patients, with deficits in tasks of processing speed, executive attention, verbal memory/learning, and visual memory. Both early- and late-stage patients had a more severe and widespread dysfunction than siblings, with no significant differences between them. Conclusions: Genetic vulnerability to BD-I seems to be associated with neurocognitive impairments, whereas social dysfunction would be the result of the clinical phenotype. Staging models of BD should take into account these divergent findings in the latent stage.
dc.language.iso	cat
dc.relation.ispartof	Frontiers In Psychiatry, 2018, vol. 9, p. 709
dc.subject	Malalties mentals
dc.subject	Neurologia
dc.title	Staging, neurocognition and social functioning in bipolar disorder.
dc.type	journal article	es_ES
dc.date.updated	2019-02-26T12:08:08Z
dc.identifier.doi	10.3389/fpsyt.2018.00709
dc.identifier.idgrec	129204
dc.rights.accessRights	open access	es_ES