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The Maternal hormone in the male brain: Sexually dimorphic distribution of prolactin signalling in the mouse brain

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The Maternal hormone in the male brain: Sexually dimorphic distribution of prolactin signalling in the mouse brain

dc.contributor.author	Salais López, Hugo
dc.contributor.author	Agustín-Pavón, Carmen
dc.contributor.author	Lanuza Navarro, Enrique
dc.contributor.author	Martínez-García, Fernando
dc.date.accessioned	2019-02-28T16:20:25Z
dc.date.available	2019-02-28T16:20:25Z
dc.date.issued	2018
dc.identifier.citation	Salais López, Hugo Agustín-Pavón, Carmen Lanuza Navarro, Enrique Martínez-García, Fernando 2018 The Maternal hormone in the male brain: Sexually dimorphic distribution of prolactin signalling in the mouse brain Plos One 13 12 e0208960
dc.identifier.uri	http://hdl.handle.net/10550/69210
dc.description.abstract	Research of the central actions of prolactin is highly focused on females, but this hormone has also documented roles in male physiology and behaviour. Here, we provide the first description of the pattern of prolactin-derived signalling in the male mouse brain, employing the immunostaining of phosphorylated signal transducer and activator of transcription 5 (pSTAT5) after exogenous prolactin administration. Next, we explore possible sexually dimorphic differences by comparing pSTAT5 immunoreactivity in prolactin-supplemented males and females. We also assess the role of testosterone in the regulation of central prolactin signalling in males by comparing intact with castrated prolactin-supplemented males. Prolactin-supplemented males displayed a widespread pattern of pSTAT5 immunoreactivity, restricted to brain centres showing expression of the prolactin receptor. Immunoreactivity for pSTAT5 was present in several nuclei of the preoptic, anterior and tuberal hypothalamus, as well as in the septofimbrial nucleus or posterodorsal medial amygdala of the telencephalon. Conversely, non-supplemented control males were virtually devoid of pSTAT5-immunoreactivity, suggesting that central prolactin actions in males are limited to situations concurrent with substantial hypophyseal prolactin release (e.g. stress or mating). Furthermore, comparison of prolactin-supplemented males and females revealed a significant, female-biased sexual dimorphism, supporting the view that prolactin has a preeminent role in female physiology and behaviour. Finally, in males, castration significantly reduced pSTAT5 immunoreactivity in some structures, including the paraventricular and ventromedial hypothalamic nuclei and the septofimbrial region, thus indicating a region-specific regulatory role of testosterone over central prolactin signalling.
dc.language.iso	eng
dc.relation.ispartof	Plos One, 2018, vol. 13, num. 12, p. e0208960
dc.subject	Cervell Localització de funcions
dc.subject	Hormones esteroides
dc.title	The Maternal hormone in the male brain: Sexually dimorphic distribution of prolactin signalling in the mouse brain
dc.type	journal article	es_ES
dc.date.updated	2019-02-28T16:20:26Z
dc.identifier.doi	10.1371/journal.pone.0208960
dc.identifier.idgrec	130265
dc.rights.accessRights	open access	es_ES