St. George was one of the best known figures in Christendom, due both to his unique story as well as for the help he gave to the various Spanish kingdoms in the fight against the enemies of Jesus Christ. His cult spread to New Spain where he was known, although not in the same manner as in Europe. But nevertheless, in the cathedral of the bishopric of Durango, the efforts of bishop Pedro Anselmo Sánchez de Tagle interests resulted in St. George being declared patron of the city in 1749 by both civil and ecclesiastical chapters. This event granted the saint another function: the fight against poisonous animals, specifically, the scorpions endemic to the region. As a result, the Saint's iconography experienced an unprecedented and meaningful change that included the depiction of a series of arachnids alongside the dragon. This is reflected in the canvas that is still located in the sacristy of this cathedral, a painting that is unique in the History of Art.   KEYWORDS: Saint George; Iconography; Bishop; Nobiliary Shield; Scorpions; Devotion; Sacristy.