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Analgesic efficacy of ketorolac associated with a tramadol/acetaminophen combination after third molar surgery - a randomized, triple-blind clinical trial

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Analgesic efficacy of ketorolac associated with a tramadol/acetaminophen combination after third molar surgery - a randomized, triple-blind clinical trial

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dc.contributor.author Martins, Luciana-Dorochenko es
dc.contributor.author Rezende, Márcia es
dc.contributor.author Dourado Loguercio, Alessandro es
dc.contributor.author Bortoluzzi, Marcelo Carlos es
dc.contributor.author Reis, Alessandra es
dc.date.accessioned 2019-03-07T13:18:59Z
dc.date.available 2019-03-07T13:18:59Z
dc.date.issued 2019 es
dc.identifier.citation Martins, Luciana-Dorochenko ; Rezende, Márcia ; Dourado Loguercio, Alessandro ; Bortoluzzi, Marcelo Carlos ; Reis, Alessandra. Analgesic efficacy of ketorolac associated with a tramadol/acetaminophen combination after third molar surgery - a randomized, triple-blind clinical trial. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 24 1 2019: 14- es
dc.identifier.uri http://hdl.handle.net/10550/69462
dc.description.abstract This study compared the efficacy of ketorolac alone versus its combination with tramadol/acetaminophen for pain control after mandibular third molar surgery. A randomized, triple-blind clinical trial was carried out with 52 patients divided into 2 groups: Group K+T+A (1 tablet of Ketorolac 10 mg plus and 1 capsule of Tramadol 37.5 mg/acetaminophen 325 mg) and Group K (1 tablet of Ketorolac 10 mg plus and 1 placebo capsule). The treatments were given 1 h before the surgery and was repeated 4 times per day, for 48 h. The difference in postoperative pain was assessed by 4 primary end-points: pain intensity (VAS 100mm, for 48 h), rescue medication, overall assessment and adverse effects. Significant differences in pain intensity were observed in the different times (p<0.05). The comparison of groups in each time showed significant differences only of 9 h, with lower level of pain intensity for group K+T+A (p = 0.005). The need of analgesics was higher in Group K (p<0.001), the need of antiemetic were greater in Group K+T+A (p<0.0001). No significant difference between groups were observed in overall assessment. The adverse effects was higher in Group K+T+A. The current study showed that both ketorolac and the combination of ketorolac plus tramadol/acetaminophen showed good control of pain after the extraction of the lower third molars. Although the combination group showed lower pain at 9 h, the difference is small and not clinically relevant. es
dc.title Analgesic efficacy of ketorolac associated with a tramadol/acetaminophen combination after third molar surgery - a randomized, triple-blind clinical trial es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.22744 es
dc.type.hasVersion VoR es_ES

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