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Typical asymmetry in the hemispheric activation during an fMRI verbal comprehension paradigm is related to better performance in verbal and non-verbal tasks in patients with epilepsy

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Typical asymmetry in the hemispheric activation during an fMRI verbal comprehension paradigm is related to better performance in verbal and non-verbal tasks in patients with epilepsy

dc.contributor.author	Cano-López, I.
dc.contributor.author	Calvo, Anna
dc.contributor.author	Boget, Teresa
dc.contributor.author	Carreño, Mar
dc.contributor.author	Donaire, Antonio
dc.contributor.author	Setoain, Xavier
dc.contributor.author	Pintor, Luis
dc.contributor.author	Rumià, Jordi
dc.contributor.author	González Bono, Esperanza
dc.contributor.author	Junqué, Carme
dc.contributor.author	Bargalló, Núria
dc.date.accessioned	2019-04-15T14:42:21Z
dc.date.available	2019-04-15T14:42:21Z
dc.date.issued	2018
dc.identifier.citation	Cano-López, I. Calvo, Anna Boget, Teresa Carreño, Mar Donaire, Antonio Setoain, Xavier Pintor, Luis Rumià, Jordi González Bono, Esperanza Junqué, Carme Bargalló, Núria 2018 Typical asymmetry in the hemispheric activation during an fMRI verbal comprehension paradigm is related to better performance in verbal and non-verbal tasks in patients with epilepsy Neuroimage-Clinical 20 742 752
dc.identifier.uri	http://hdl.handle.net/10550/69986
dc.description.abstract	Chronic exposure to seizures in patients with left hemisphere (LH) epileptic focus could favor higher activation in the contralateral hemisphere during language processing, but the cognitive effects of this remain unclear. This study assesses the relationship between asymmetry in hemispheric activation during language fMRI and performance in verbal and non-verbal tasks. Whereas prior studies primarily used fMRI paradigms that favor frontal lobe activation and less prominent activation of the medial or superior temporal lobes, we used a verbal comprehension paradigm previously demonstrated to activate reliably receptive language areas. Forty-seven patients with drug-resistant epilepsy candidates for surgery underwent a multidisciplinary assessment, including a comprehensive neuropsychological evaluation and an fMRI verbal comprehension paradigm. Patients were distributed in two groups depending on laterality indexes (LI): typical hemispheric asymmetry (unilateral left activation preponderance; n = 23) and atypical hemispheric asymmetry (bilateral or unilateral right preponderance; n = 24). Right-handedness and right hemisphere (RH) focus were significant predictors of typical asymmetry. Patients with typical activation pattern presented better performance intelligence quotient and verbal learning than patients with atypical hemispheric asymmetry (for all, p < 0.014). Patients with LH focus had more frequently atypical hemispheric asymmetry than patients with RH focus (p = 0.05). Specifically, they showed lower LI and this was related to worse performance in verbal and non-verbal tasks. In conclusion, an increased activation of homologous RH areas for verbal comprehension processing could imply a competition of cognitive resources in the performance of the same task, disrupting cognitive performance.
dc.language.iso	eng
dc.relation.ispartof	Neuroimage-Clinical, 2018, vol. 20, p. 742-752
dc.subject	Psicobiologia
dc.subject	Cervell Localització de funcions
dc.title	Typical asymmetry in the hemispheric activation during an fMRI verbal comprehension paradigm is related to better performance in verbal and non-verbal tasks in patients with epilepsy
dc.type	journal article	es_ES
dc.date.updated	2019-04-15T14:42:21Z
dc.identifier.doi	10.1016/j.nicl.2018.09.010
dc.identifier.idgrec	131152
dc.rights.accessRights	open access	es_ES