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The Effect of Moderate- Versus High-Intensity Resistance Training on Systemic Redox State and DNA Damage in Healthy Older Women

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The Effect of Moderate- Versus High-Intensity Resistance Training on Systemic Redox State and DNA Damage in Healthy Older Women

dc.contributor.author	Gargallo Bayo, Pedro
dc.contributor.author	Colado Sánchez, Juan Carlos
dc.contributor.author	Juesas, Alvaro
dc.contributor.author	Hernando-Espinilla, Amaya
dc.contributor.author	Estañ Capell, Nuria
dc.contributor.author	Monzó-Beltran, Lidia
dc.contributor.author	García-Pérez, Paula
dc.contributor.author	Cauli, Omar
dc.contributor.author	Sáez Tormo, Guillermo
dc.date.accessioned	2019-05-17T13:50:55Z
dc.date.available	2019-05-17T13:50:55Z
dc.date.issued	2018
dc.identifier.citation	Gargallo Bayo, Pedro Colado Sánchez, Juan Carlos Juesas, Alvaro Hernando-Espinilla, Amaya Estañ Capell, Nuria Monzó-Beltran, Lidia García-Pérez, Paula Cauli, Omar Sáez Tormo, Guillermo 2018 The Effect of Moderate- Versus High-Intensity Resistance Training on Systemic Redox State and DNA Damage in Healthy Older Women Biological Research For Nursing 20 2 205 217
dc.identifier.uri	http://hdl.handle.net/10550/70228
dc.description.abstract	This study investigated effects of a 16-week progressive resistance training program (RTP) with elastic bands at two different intensities on systemic redox state, DNA damage, and physical function in healthy older women. METHODS: Participants were randomly assigned to the high-intensity group (HIGH; n = 39), moderate-intensity group (MOD; n = 31), or control group (CG; n = 23). The exercise groups performed an RTP twice a week with three to four sets of 6 (HIGH) or 15 (MOD) repetitions of six overall body exercises at a perceived exertion rate of 8-9 on the OMNI-Resistance Exercise Scale for use with elastic bands. Thiol redox state was determined by reduced glutathione (GSH), oxidized glutathione (GSSG), and GSSG/GSH in blood mononuclear cells. Degree of DNA damage was assessed by presence of the oxidized DNA base molecule 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-OHdG) in urine. Physical function monitoring was based on the arm curl, chair stand, up and go, and 6-min walk tests. RESULTS: The HIGH group showed a significant increase in 8-OHdG (+71.07%, effect size [ES] = 1.12) and a significant decrease in GSH (-10.91, ES = -0.69), while the MOD group showed a significant decrease in 8-OHdG levels (-25.66%, ES = -0.69) with no changes in thiol redox state. GSH levels differed significantly between the HIGH and CG groups posttest. The exercise groups showed significant improvements in physical function with no differences between groups. CONCLUSION: RTP at a moderate rather than high intensity may be a better strategy to reduce DNA damage in healthy older women while also increasing independence.
dc.language.iso	eng
dc.relation.ispartof	Biological Research For Nursing, 2018, vol. 20, num. 2, p. 205-217
dc.subject	Estrès oxidatiu
dc.subject	Entrenament (Esport)
dc.title	The Effect of Moderate- Versus High-Intensity Resistance Training on Systemic Redox State and DNA Damage in Healthy Older Women
dc.type	journal article	es_ES
dc.date.updated	2019-05-17T13:50:56Z
dc.identifier.doi	10.1177/1099800417753877
dc.identifier.idgrec	125578
dc.rights.accessRights	open access	es_ES