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Lipid profile, cardiovascular disease and mortality in a Mediterranean high-risk population: the ESCARVAL-RISK study

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Lipid profile, cardiovascular disease and mortality in a Mediterranean high-risk population: the ESCARVAL-RISK study

dc.contributor.author	Orozco Beltrán, Domingo
dc.contributor.author	Gil Guillen, Vicente F.
dc.contributor.author	Redón i Más, Josep
dc.contributor.author	Martín Moreno, José María
dc.contributor.author	Pallares, Vicente
dc.contributor.author	Navarro Pérez, Jorge
dc.contributor.author	Valls-Roca, Francisco
dc.contributor.author	Sanchis-Domenech, Carlos
dc.contributor.author	Fernández-Gimenez, Antonio
dc.contributor.author	Perez-Navarro, Ana
dc.contributor.author	Bertomeu-Martinez, Vicente
dc.contributor.author	Bertomeu-González, Vicente
dc.contributor.author	Cordero, Alberto
dc.contributor.author	Pascual-de-la-Torre, Manuel
dc.contributor.author	Trillo-Mata, Jose Luis
dc.contributor.author	Carratalá Munuera, Concepción
dc.contributor.author	Pita Fernández, Salvador
dc.contributor.author	Usó Talamantes, Ruth
dc.contributor.author	Durazo Arvizu, Ramón
dc.contributor.author	Cooper, Richard
dc.contributor.author	Sanz, Ginés
dc.contributor.author	Castellano, Jose M.
dc.contributor.author	Ascaso Gimilio, Juan Francisco
dc.contributor.author	Carmena Rodriguez, Rafael
dc.contributor.author	Tellez-Plaza, María
dc.contributor.author	ESCARVAL Study Group.
dc.date.accessioned	2019-05-24T12:05:17Z
dc.date.available	2019-05-24T12:05:17Z
dc.date.issued	2017
dc.identifier.citation	Orozco Beltrán, Domingo Gil Guillen, Vicente F. Redón i Mas, Josep Martín Moreno, Jose María Pallares, Vicente Navarro Pérez, Jorge Valls-Roca, Francisco Sanchis-Domenech, Carlos Fernández-Gimenez, Antonio Perez-Navarro, Ana Bertomeu-Martinez, Vicente Bertomeu-González, Vicente Cordero, Alberto Pascual-de-la-Torre, Manuel Trillo, Jose L. Carratalá Munuera, Concepción Pita Fernández, Salvador Uso, Ruth Durazo Arvizu, Ramón Cooper, Richard Sanz, Ginés Castellano, Jose M. Ascaso Gimilio, Juan Francisco Carmena Rodriguez, Rafael Tellez-Plaza, María ESCARVAL Study Group. 2017 Lipid profile, cardiovascular disease and mortality in a Mediterranean high-risk population: the ESCARVAL-RISK study Plos One 12 10 e0186196 - 1 20
dc.identifier.uri	https://hdl.handle.net/10550/70294
dc.description.abstract	The potential impact of targeting different components of an adverse lipid profile in populations with multiple cardiovascular risk factors is not completely clear. This study aims to assess the association between different components of the standard lipid profile with all cause mortality and hospitalization due to cardiovascular events in a high-risk population. Methods This prospective registry included high risk adults over 30 years old free of cardiovascular disease (2008±2012). Diagnosis of hypertension, dyslipidemia or diabetes mellitus was inclusion criterion. Lipid biomarkers were evaluated. Primary endpoints were all-cause mortality and hospital admission due to coronary heart disease or stroke. We estimated adjusted rate ratios (aRR), absolute risk differences and population attributable risk associated with adverse lipid profiles. Results 51,462 subjects were included with a mean age of 62.6 years (47.6% men). During an average follow-up of 3.2 years, 919 deaths, 1666 hospitalizations for coronary heart disease and 1510 hospitalizations for stroke were recorded. The parameters that showed an increased rate for total mortality, coronary heart disease and stroke hospitalization were, respectively, low HDL-Cholesterol: aRR 1.25, 1.29 and 1.23; high Total/HDL-Cholesterol: aRR 1.22, 1.38 and 1.25; and high Triglycerides/HDL-Cholesterol: aRR 1.21, 1.30, 1.09. The parameters that showed highest population attributable risk (%) were, respectively, low HDL-Cholesterol: 7.70, 11.42, 8.40; high Total/HDL-Cholesterol: 6.55, 12.47, 8.73; and high Triglycerides/ HDL-Cholesterol: 8.94, 15.09, 6.92. Conclusions In a population with cardiovascular risk factors, HDL-cholesterol, Total/HDL-cholesterol and triglycerides/HDL-cholesterol ratios were associated with a higher population attributable risk for cardiovascular disease compared to other common biomarkers.
dc.language.iso	eng
dc.relation.ispartof	Plos One, 2017, vol. 12, num. 10, p. e0186196 - 1-20
dc.subject	Obesitat
dc.subject	Sistema cardiovascular
dc.subject	Mortalitat
dc.title	Lipid profile, cardiovascular disease and mortality in a Mediterranean high-risk population: the ESCARVAL-RISK study
dc.type	journal article	es_ES
dc.date.updated	2019-05-24T12:05:17Z
dc.identifier.doi	10.1371/journal.pone.0186196
dc.identifier.idgrec	120838
dc.rights.accessRights	open access	es_ES