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Digital holographic microscopy as a screening technology for diabetes

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Digital holographic microscopy as a screening technology for diabetes

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dc.contributor.author	Doblas Expósito, Ana Isabel
dc.contributor.author	García Sucerquia, Jorge Iván
dc.contributor.author	Saavedra Tortosa, Genaro
dc.contributor.author	Martínez Corral, Manuel
dc.date.accessioned	2019-06-18T12:45:25Z
dc.date.available	2019-06-18T12:45:25Z
dc.date.issued	2019
dc.identifier.citation	Doblas Expósito, Ana Isabel García Sucerquia, Jorge Iván Saavedra Tortosa, Genaro Martínez Corral, Manuel 2019 Digital holographic microscopy as a screening technology for diabetes Proceedings of the SPIE 10997 1 7
dc.identifier.uri	https://hdl.handle.net/10550/70496
dc.description.abstract	Label-free quantitative phase imaging (QPI) is the hallmark of digital holographic microscopy (DHM). One of the most interesting medical applications of QPI-DHM is that it can be used to analyze illnesses in which the refractive index or/and the morphology of cells/tissues are distorted, from the acquisition of a single image. In this contribution, we obtain the phase maps of red blood cells (RBCs) samples of patients suffering from diabetes mellitus type 1 (DM1) by using a DHM. Our experimental results show that the measured phase values are significantly different between control non-diabetic and diabetic patients. The high correlation coefficient between the phase and the glycated hemoglobin (HbA1C) values determined by the gold standard method to screen diabetes and the clear separation between the two groups indicate that DHM may potentially be used to evaluate long-term glycemic control in diabetic patients as well as to diagnose diabetes.
dc.language.iso	eng
dc.relation.ispartof	Proceedings of the SPIE, 2019, vol. 10997, p. 1-7
dc.subject	Microscòpia
dc.subject	Òptica Aparells i instruments
dc.title	Digital holographic microscopy as a screening technology for diabetes
dc.type	journal article	es_ES
dc.date.updated	2019-06-18T12:45:25Z
dc.identifier.doi	10.1117/12.2523416
dc.identifier.idgrec	133399
dc.rights.accessRights	open access	es_ES