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CD73 a novel marker for the diagnosis of benign and malignant salivary gland tumors

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CD73 a novel marker for the diagnosis of benign and malignant salivary gland tumors

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dc.contributor.author Ranjbar, Mohammad-Ali es
dc.contributor.author Ranjbar, Zahra es
dc.contributor.author Zahed, Maryam es
dc.contributor.author Nikookar, Negar es
dc.date.accessioned 2019-07-02T09:24:43Z
dc.date.available 2019-07-02T09:24:43Z
dc.date.issued 2019 es
dc.identifier.citation Ranjbar, Mohammad-Ali ; Ranjbar, Zahra ; Zahed, Maryam ; Nikookar, Negar. CD73 a novel marker for the diagnosis of benign and malignant salivary gland tumors. En: Journal of Clinical and Experimental Dentistry, 11 3 2019: 213-218 es
dc.identifier.uri https://hdl.handle.net/10550/70636
dc.description.abstract Ecto-5?-nucleotidase (CD73) plays an important role in the development of several types of cancer; however, its prognostic significance in salivary gland tumors remains unknown. The current study was conducted to investigate the expression of CD73 in such tumors. In this retrospective study, immunohistochemical expression of CD73 was evaluated in 25 pleomorphic adenomas, 20 mucoepidermoid carcinomas and 20 adenoid cystic carcinomas using the Envision technique. Labeling indices of CD73 expression were calculated and compared between lesions. Immunohistochemical analysis demonstrated that the CD73 expression was significantly higher in salivary gland tumors than in normal salivary gland tissue (p<0.001). CD73 expression was significantly higher in mucoepidermoid carcinoma and adenoid cystic carcinoma compared to pleomorphic adenoma p<0.001). In addition, the expression of CD73 was significantly higher in lymph node metastasizing cancers compared to non-metastasizing malignancies (P<0.001). In contrast, there was no significant association between CD73 expression and other clinicopathological variables such as age, gender, tumor size and distant metastasis (P>0.05). The findings suggest that CD73 can be an independent and useful biomarker for predicting the clinical behavior of salivary gland tumors. es
dc.title CD73 a novel marker for the diagnosis of benign and malignant salivary gland tumors es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/jced.54918 es
dc.type.hasVersion VoR es_ES

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