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Animal models in the study and treatment of orofacial pain

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Animal models in the study and treatment of orofacial pain

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dc.contributor.author Martínez-García, Miguel-Ángel es
dc.contributor.author Migueláñez-Medrán, Blanca C. es
dc.contributor.author Goicoechea García, Carlos es
dc.date.accessioned 2019-07-02T09:25:00Z
dc.date.available 2019-07-02T09:25:00Z
dc.date.issued 2019 es
dc.identifier.citation Martínez-García, Miguel-Ángel ; Migueláñez-Medrán, Blanca C. ; Goicoechea García, Carlos. Animal models in the study and treatment of orofacial pain. En: Journal of Clinical and Experimental Dentistry, 11 4 2019: 382-390 es
dc.identifier.uri https://hdl.handle.net/10550/70646
dc.description.abstract Pain is one of the first causes of medical consultation in the world and by extension of dental consultation too. Orofacial pain comprehends the oral and facial regions including teeth, oral mucosa, gingiva, tongue and lips, but also the muscles of the jaw and neck, the temporomandibular joint, face, head and neck. Despite its highly estimated prevalence, it appears controversial and hard to quantify given the lack of common criteria to select the population under study and the difficulties to classify the different types of pain. Although for many patients the problem eventually fades after tissue healing, certain sub-chronic and chronic pain conditions remain notoriously undertreated. In this respect, animal models can be of great help. A systematic search was conducted in PubMed-Medline with appropriate keywords: orofacial pain, prevalence and dentist. Seven groups were generated and a second search based on each of these groups and on animal models was made. Search was restricted to English and Spanish, but no time restriction was applied. There are as yet few experimental models of orofacial pain: there hardly exists no other than trigeminal nerve injury for neuropathic pain, a bunch of oral squamous cell carcinoma models (mainly referred to the tongue) for cancer pain and none for the painful swelling of salivary glands. Similarly occurs for the burning mouth syndrome. A few more exist for inflammatory odontalgiae, aphthae, joint, myofascial and muscle inflammatory pains, although scarcely diverse as regards the nature of the noxious stimulus. Given the relevance of envisaging the mechanistic of the various types of orofacial pain, new experimental models are needed on the basis of the dentist?s perspective for their correct management. es
dc.title Animal models in the study and treatment of orofacial pain es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/jced.55429 es
dc.type.hasVersion VoR es_ES

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