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Detection of Type VII collagen in odontogenic keratocyst : an immunohistochemical study

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Detection of Type VII collagen in odontogenic keratocyst : an immunohistochemical study

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dc.contributor.author Cota, Jochima-Eudora es
dc.contributor.author Spadigam, Anita es
dc.contributor.author Dhupar, Anita es
dc.date.accessioned 2019-07-02T09:25:55Z
dc.date.available 2019-07-02T09:25:55Z
dc.date.issued 2019 es
dc.identifier.citation Cota, Jochima-Eudora ; Spadigam, Anita ; Dhupar, Anita. Detection of Type VII collagen in odontogenic keratocyst : an immunohistochemical study. En: Journal of Clinical and Experimental Dentistry, 11 4 2019: 310-314 es
dc.identifier.uri https://hdl.handle.net/10550/70654
dc.description.abstract Separation of the epithelial lining from the underlying connective tissue wall has been a frequently observed and unique feature in odontogenic keratocysts (OKC), but not in other odontogenic cysts nor neoplasms. No study on OKC has been reported evaluating the role of type VII Collagen, the anchoring fibrils, which function in stabilising the epithelial structure. The purpose of this study was to assess the role of type VII collagen in the fragility of the epithelium leading to a high recurrence rate in OKCs. Immunohistochemical staining with Abcam® Monoclonal Mouse Anti-Collagen VII Antibody [LH7.2] (used at a dilution of 1:200) on 30 tissues of OKC. The chi-square test was applied to confirm the statistical significance between the control and test groups. The frequencies of the pattern of distribution for the staining characteristics of collagen VII were calculated in the OKC samples. Out of the 30 OKC samples 22 (73.3%) showed negative staining for type VII Collagen. Among the infected cases, 7 showed a positive basement membrane staining and one of the non-infected OKC showed positive basement membrane staining. However, none of the syndrome associated or recurrent OKCs showed any evidence of type VII collagen reactivity. Considering the distribution of type VII collagen in OKCs it can be concluded that type VII collagen expression is altered in OKCs, leading to destabilisation of the epithelium connective tissue interface thus rendering the epithelium-connective tissue interface fragile. es
dc.title Detection of Type VII collagen in odontogenic keratocyst : an immunohistochemical study es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/jced.54946 es
dc.type.hasVersion VoR es_ES

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