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The telomeric Cdc13-Stn1-Ten1 complex regulates RNA polymerase II transcription

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The telomeric Cdc13-Stn1-Ten1 complex regulates RNA polymerase II transcription

dc.contributor.author	Calvo, Olga
dc.contributor.author	Grandin, Nathalie
dc.contributor.author	Jordán Plá, Antonio
dc.contributor.author	Miñambres, Esperanza
dc.contributor.author	González-Polo, Noelia
dc.contributor.author	Pérez Ortín, José Enrique
dc.contributor.author	Charbonneau, Michel
dc.date.accessioned	2019-07-12T13:15:41Z
dc.date.available	2019-07-12T13:15:41Z
dc.date.issued	2019
dc.identifier.citation	Calvo, Olga Grandin, Nathalie Jordán Plá, Antonio Miñambres, Esperanza González-Polo, Noelia Pérez Ortín, José Enrique Charbonneau, Michel 2019 The telomeric Cdc13-Stn1-Ten1 complex regulates RNA polymerase II transcription Nucleic Acids Research 47 12 6250 6268
dc.identifier.uri	https://hdl.handle.net/10550/70810
dc.description.abstract	Specialized telomeric proteins have an essential role in maintaining genome stability through chromosome end protection and telomere length regulation. In the yeast Saccharomyces cerevisiae, the evolutionary conserved CST complex, composed of the Cdc13, Stn1 and Ten1 proteins, largely contributes to these functions. Here, we report genetic interactions between TEN1 and several genes coding for transcription regulators. Molecular assays confirmed this novel function of Ten1 and further established that it regulates the occupancies of RNA polymerase II and the Spt5 elongation factor within transcribed genes. Since Ten1, but also Cdc13 and Stn1, were found to physically associate with Spt5, we propose that Spt5 represents the target of CST in transcription regulation. Moreover, CST physically associates with Hmo1, previously shown to mediate the architecture of S-phase transcribed genes. The fact that, genomewide, the promoters of genes down-regulated in the ten1-31 mutant are prefentially bound by Hmo1, leads us to propose a potential role for CST in synchronizing transcription with replication fork progression following head-on collisions.
dc.language.iso	eng
dc.relation.ispartof	Nucleic Acids Research, 2019, vol. 47, num. 12, p. 6250-6268
dc.subject	Genomes
dc.subject	Cromosomes
dc.title	The telomeric Cdc13-Stn1-Ten1 complex regulates RNA polymerase II transcription
dc.type	journal article	es_ES
dc.date.updated	2019-07-12T13:15:42Z
dc.identifier.doi	10.1093/nar/gkz279
dc.identifier.idgrec	133516
dc.rights.accessRights	open access	es_ES