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Blood cell transcript levels in 5-year-old children as potential markers of breastfeeding effects in those small for gestational age at birth

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Blood cell transcript levels in 5-year-old children as potential markers of breastfeeding effects in those small for gestational age at birth

dc.contributor.author	Álvarez Pitti, Julio Carlos
dc.contributor.author	Ros Forés, María Amparo
dc.contributor.author	Bayo Pérez, Ana
dc.contributor.author	Palou, Mariona
dc.contributor.author	Lurbe i Ferrer, Empar
dc.contributor.author	Palou, Andreu
dc.contributor.author	Picó, Catalina
dc.date.accessioned	2019-10-03T11:39:42Z
dc.date.available	2019-10-03T11:39:42Z
dc.date.issued	2019
dc.identifier.citation	Álvarez Pitti, Julio Carlos Ros Forés, María Amparo Bayo Pérez, Ana Palou, Mariona Lurbe i Ferrer, Empar Palou, Andreu Picó, Catalina 2019 Blood cell transcript levels in 5-year-old children as potential markers of breastfeeding effects in those small for gestational age at birth. Journal Of Translational Medicine 17 1 145 145
dc.identifier.uri	https://hdl.handle.net/10550/71664
dc.description.abstract	BACKGROUND: Nutrition of the newborn during the early postnatal period seems to be of capital importance and there is clinical evidence showing the protective effect of breastfeeding compared with formula feeding on childhood obesity and its comorbidities. Infants born small for gestation age may be more sensitive to the type of feeding during lactation. Here, we aimed to analyze the impact of birth weight and the type of infant feeding on the expression levels in peripheral blood cells of selected candidate genes involved in energy homeostasis in 5-year-old children, to find out potential early biomarkers of metabolic programming effects during this period of metabolic plasticity. METHODS: Forty subjects were recruited at birth and divided in four groups according to birth weight (adequate or small for gestational age) and type of infant feeding (breastfeeding or formula feeding). They were followed from birth to the age of 5 years. RESULTS: At 5 years, no significant differences regarding anthropometric parameters were found between groups, and all children had normal biochemical values. Expression levels of UCP2 and MC4R in peripheral blood cells were lower and higher, respectively, in formula feeding children compared with breastfeeding ones (P = 0.002 and P = 0.064, two-way ANOVA). Differences were more marked and significant by Student's t test in small for gestation age children (P < 0.001 and P = 0.017, respectively). Transcript levels of FASN and FTO in peripheral blood cells were also different according to the type of infant feeding, but only in small for gestation age children. CONCLUSIONS: Altogether, these results suggest that small for gestation age infants are more sensitive to the type of feeding during lactation, and transcript levels of particular genes in peripheral blood cells, especially the MC4R/UCP2 mRNA ratio, may precisely reflect these effects in the absence of clear differences in phenotypic traits.
dc.language.iso	cat
dc.relation.ispartof	Journal Of Translational Medicine, 2019, vol. 17, num. 1, p. 145-145
dc.subject	Infants
dc.subject	Sang
dc.title	Blood cell transcript levels in 5-year-old children as potential markers of breastfeeding effects in those small for gestational age at birth
dc.type	journal article	es_ES
dc.date.updated	2019-10-03T11:39:42Z
dc.identifier.doi	10.1186/s12967-019-1896-1
dc.identifier.idgrec	134653
dc.rights.accessRights	open access	es_ES