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Phylogeny of Vibrio vulnificus from the analysis of the core-genome: implications for intra-species taxonomy

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Phylogeny of Vibrio vulnificus from the analysis of the core-genome: implications for intra-species taxonomy

dc.contributor.author	Roig Molina, Francisco José
dc.contributor.author	González Candelas, Fernando
dc.contributor.author	Sanjuán Caro, Eva
dc.contributor.author	Fouz Rodríguez, Belén
dc.contributor.author	Feil, Edward J.
dc.contributor.author	Llorens, Carlos
dc.contributor.author	Baker-Austin, Craig
dc.contributor.author	Oliver, James D.
dc.contributor.author	Danin-Poleg, Yael
dc.contributor.author	Gibas, C.J.
dc.contributor.author	Kashi, Yechezkel
dc.contributor.author	Gulig, Paul A.
dc.contributor.author	Morrison, S.S.
dc.contributor.author	Amaro González, Carmen
dc.date.accessioned	2019-10-03T13:09:19Z
dc.date.available	2019-10-03T13:09:19Z
dc.date.issued	2018
dc.identifier.citation	Roig Molina, Francisco José González Candelas, Fernando Sanjuán Caro, Eva Fouz Rodríguez, Belén Feil, Edward J. Llorens, Carlos Baker-Austin, Craig Oliver, James D. Danin-Poleg, Yael Gibas, C.J. Kashi, Yechezkel Gulig, Paul A. Morrison, S.S. Amaro González, Carmen 2018 Phylogeny of Vibrio vulnificus from the analysis of the core-genome: implications for intra-species taxonomy Frontiers In Microbiology 8 2613
dc.identifier.uri	https://hdl.handle.net/10550/71665
dc.description.abstract	Vibrio vulnificus (Vv) is a multi-host pathogenic species currently subdivided into three biotypes (Bts). The three Bts are human-pathogens, but only Bt2 is also a fish-pathogen, an ability that is conferred by a transferable virulence-plasmid (pVvbt2). Here we present a phylogenomic analysis from the core genome of 80 Vv strains belonging to the three Bts recovered from a wide range of geographical and ecological sources. We have identified five well-supported phylogenetic groups or lineages (L). LI comprises a mixture of clinical and environmental Bt1 strains, most of them involved in human clinical cases related to raw seafood ingestion. LII is linked to the aquaculture industry and includes Bt3 strains exclusively, mostly related to wound infections or secondary septicemia after farmed-fish handling. LIII is formed by a mixture of Bt1 and Bt2 strains from various sources, including diseased fish, and is also related to the aquaculture industry. Lastly, LIV and LV include a few strains of Bt1 associated with specific geographical areas. The phylogenetic trees for ChrI and II are not congruent to one another, which suggests that inter- and/or intra-chromosomal rearrangements have been produced along Vv evolution. Further, the phylogenetic trees for each chromosome and the virulence plasmid were also not congruent, which also suggests that pVvbt2 has been acquired independently by different clones, probably in fish farms. From all these clones, the one with zoonotic capabilities (Bt2-Serovar E) has successfully spread worldwide. From these results, we propose a new updated classification of the species based on phylogenetic lineages rather than on Bts, as well as the inclusion of all Bt2 strains in a pathovar with the particular ability to cause fish vibriosis, for which we suggest the name 'piscis'.
dc.language.iso	eng
dc.relation.ispartof	Frontiers In Microbiology, 2018, vol. 8, p. 2613
dc.subject	Bacteris patògens
dc.subject	Microbiologia
dc.title	Phylogeny of Vibrio vulnificus from the analysis of the core-genome: implications for intra-species taxonomy
dc.type	journal article	es_ES
dc.date.updated	2019-10-03T13:09:19Z
dc.identifier.doi	10.3389/fmicb.2017.02613
dc.identifier.idgrec	122357
dc.rights.accessRights	open access	es_ES