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Performance of polyester-based electrospun scaffolds under in vitro hydrolytic conditions: From short-term to long-term applications

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Performance of polyester-based electrospun scaffolds under in vitro hydrolytic conditions: From short-term to long-term applications

dc.contributor.author	Gil Castell, O.
dc.contributor.author	Badia Valiente, José David
dc.contributor.author	Bou, Jordi
dc.contributor.author	Ribes Greus, A.
dc.date.accessioned	2019-10-23T14:13:15Z
dc.date.available	2019-10-23T14:13:15Z
dc.date.issued	2019
dc.identifier.citation	Gil Castell, O. Badia Valiente, José David Bou, Jordi Ribes Greus, A. 2019 Performance of polyester-based electrospun scaffolds under in vitro hydrolytic conditions: From short-term to long-term applications Nanomaterials 9 5 786
dc.identifier.uri	https://hdl.handle.net/10550/71802
dc.description.abstract	The evaluation of the performance of polyesters under in vitro physiologic conditions is essential to design scaffolds with an adequate lifespan for a given application. In this line, the degradation-durability patterns of poly(lactide-co-glycolide) (PLGA), polydioxanone (PDO), polycaprolactone (PCL) and polyhydroxybutyrate (PHB) scaffolds were monitored and compared giving, as a result, a basis for the specific design of scaffolds from short-term to long-term applications. For this purpose, they were immersed in ultra-pure water and phosphate buffer solution (PBS) at 37 °C. The scaffolds for short-time applications were PLGA and PDO, in which the molar mass diminished down to 20% in a 20-30 days lifespan. While PDO developed crystallinity that prevented the geometry of the fibres, those of PLGA coalesced and collapsed. The scaffolds for long-term applications were PCL and PHB, in which the molar mass followed a progressive decrease, reaching values of 10% for PCL and almost 50% for PHB after 650 days of immersion. This resistant pattern was mainly ascribed to the stability of the crystalline domains of the fibres, in which the diameters remained almost unaffected. From the perspective of an adequate balance between the durability and degradation, this study may serve technologists as a reference point to design polyester-based scaffolds for biomedical applications.
dc.language.iso	eng
dc.relation.ispartof	Nanomaterials, 2019, vol. 9, num. 5, p. 786
dc.subject	Nanotecnologia
dc.subject	Termoplàstics
dc.title	Performance of polyester-based electrospun scaffolds under in vitro hydrolytic conditions: From short-term to long-term applications
dc.type	journal article	es_ES
dc.date.updated	2019-10-23T14:13:15Z
dc.identifier.doi	10.3390/nano9050786
dc.identifier.idgrec	134924
dc.rights.accessRights	open access	es_ES