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Bisphosphonate-related osteonecrosis. Application of adipose-derived stem cells in an experimental murine model

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Bisphosphonate-related osteonecrosis. Application of adipose-derived stem cells in an experimental murine model

dc.contributor.author	Alonso Rodríguez, Estefanía	es
dc.contributor.author	González Martín-Moro, Javier	es
dc.contributor.author	Cebrián Carretero, José Luis	es
dc.contributor.author	Castillo Pardo de Vera, José Luis del	es
dc.contributor.author	Pozo Kreilinger, Jose Juan	es
dc.contributor.author	Ruiz Bravo, Elena	es
dc.contributor.author	García Arranz, Mariano Andrés	es
dc.contributor.author	Hernandez Godoy, Juan	es
dc.contributor.author	Burgueño García, Miguel	es
dc.date.accessioned	2019-11-06T12:50:37Z
dc.date.available	2019-11-06T12:50:37Z
dc.date.issued	2019	es
dc.identifier.citation	Alonso Rodríguez, Estefanía ; González Martín-Moro, Javier ; Cebrián Carretero, José Luis ; Castillo Pardo de Vera, José Luis del ; Pozo Kreilinger, Jose Juan ; Ruiz Bravo, Elena ; García Arranz, Mariano Andrés ; Hernandez Godoy, Juan ; Burgueño García, Miguel. Bisphosphonate-related osteonecrosis. Application of adipose-derived stem cells in an experimental murine model. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 24 4 2019: 12-	es
dc.identifier.uri	https://hdl.handle.net/10550/72052
dc.description.abstract	Bisphosphonate-related osteonecrosis of the jaw is a pathological condition without effective established treatment and preventive strategies. The aim of this study was to analyse the effect of adipose-derived stem cells (ASC) in an experimental murine model of osteonecrosis. 38 Wistar rats were injected intraperitoneally with zoledronic acid. After treatment, upper jaw molars were extracted. The animals were randomly assigned to one of two groups. In the control group, saline solution was applied over the alveolar sockets after the tooth extractions. In the treatment group, ASCs were applied instead of saline solution. The control and treatment groups were subdivided based on the time of euthanasia. A clinical and histological analysis was performed. The presence of osteonecrosis in alveolar bone was observed in a similar distribution in both groups. In the ASC-treated group, new bone formation was greater than in controls. In this study, application of ASCs showed greater new bone formation in an osteonecrosis-like murine model. Previous inhibited post-extraction bone remodelling could be reactivated, and these findings appeared to be secondary to implantation of ASCs.	es
dc.title	Bisphosphonate-related osteonecrosis. Application of adipose-derived stem cells in an experimental murine model	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO::CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.22959	es
dc.type.hasVersion	VoR	es_ES