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Salivary myeloperoxidase and malondialdehyde are increased in patients exhibiting an asymptomatic mandibular impacted third molar

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Salivary myeloperoxidase and malondialdehyde are increased in patients exhibiting an asymptomatic mandibular impacted third molar

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dc.contributor.author Camacho Alonso, Fabio es
dc.contributor.author Tudela-Mulero, María del Rosario es
dc.contributor.author Peñarrocha Oltra, David es
dc.contributor.author Peñarrocha Diago, Miguel es
dc.contributor.author Balaguer Martí, José Carlos es
dc.contributor.author Sánchez Siles, Mariano Alberto es
dc.date.accessioned 2019-11-06T12:51:15Z
dc.date.available 2019-11-06T12:51:15Z
dc.date.issued 2019 es
dc.identifier.citation Camacho Alonso, Fabio ; Tudela-Mulero, María del Rosario ; Peñarrocha Oltra, David ; Peñarrocha Diago, Miguel ; Balaguer Martí, José Carlos ; Sánchez Siles, Mariano Alberto. Salivary myeloperoxidase and malondialdehyde are increased in patients exhibiting an asymptomatic mandibular impacted third molar. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 24 4 2019: 13- es
dc.identifier.uri https://hdl.handle.net/10550/72053
dc.description.abstract To determine whether saliva is a good means of evaluating concentrations of oxidative stress biomarkers, analyzing the correlation between concentrations in saliva and in follicular tissue, and to compare biomarker concentrations in patients with one asymptomatic mandibular impacted third molar (MITM) (before extraction) with a healthy control, and to determine how biomarkers are modified by extraction. 80 patients with one asymptomatic MITM and 80 healthy controls were included. Saliva samples were collected from all subjects (before extraction in the study group) to evaluate Myeloperoxidase (MPO) and Malondialdehyde (MDA) concentrations. Follicular tissues were obtained during surgery to measure biomarkers. One month after extraction, saliva samples were collected to assess changes of oxidative stress. Salivary MPO and MDA showed positive correlation with concentrations in follicular tissue (MPO: correlation coefficient=0.72, p=0.025; MDA: =0.92, p=0.001). Patients with asymptomatic MITMs showed higher salivary concentrations of oxidative stress biomarkers than healthy control subjects, with statistical significance for both MPO (p<0.001) and MDA (p<0.001). One month after extraction, salivary biomarkers decreased significantly in the study group (p<0.001). Salivary MPO and MDA are higher among patients with one asymptomatic MITM, but these levels decrease significantly one month after surgical extraction. The large decrease in oxidative stress biomarkers could justify third molar extraction despite the absence of symptoms. es
dc.title Salivary myeloperoxidase and malondialdehyde are increased in patients exhibiting an asymptomatic mandibular impacted third molar es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.22962 es
dc.type.hasVersion VoR es_ES

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