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Effects of locally applied Insulin-like Growth Factor-I on osseointegration

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Effects of locally applied Insulin-like Growth Factor-I on osseointegration

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dc.contributor.author López Quiles, Juan es
dc.contributor.author Forteza-López, Alba es
dc.contributor.author Montiel, Mónica es
dc.contributor.author Clemente de Arriba, Celia es
dc.contributor.author Fernández-Tresguerres Hernández, Jesús A. es
dc.contributor.author Fernández Tresguerres, Isabel es
dc.date.accessioned 2019-11-06T12:51:54Z
dc.date.available 2019-11-06T12:51:54Z
dc.date.issued 2019 es
dc.identifier.citation López Quiles, Juan ; Forteza-López, Alba ; Montiel, Mónica ; Clemente de Arriba, Celia ; Fernández-Tresguerres Hernández, Jesús A. ; Fernández Tresguerres, Isabel. Effects of locally applied Insulin-like Growth Factor-I on osseointegration. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 24 5 2019: 11- es
dc.identifier.uri https://hdl.handle.net/10550/72069
dc.description.abstract The aim of this study was to assess the effect of local application of IGF-I on osseointegration of dental implants placed in osteoporotic bones. 16 rabbits were randomly distributed into two groups: eight animals were ovariectomized and fed a low-calcium diet for six weeks, in order to induce experimental osteoporosis, and the others were sham-operated and fed a standard diet. A titanium implant was inserted into the tibiae in both groups. In half of the rabbits, 4 ?g of IGF-I was applied into the ostectomy, prior to the implant insertion. A total of 32 implants were placed. Animals were sacrificed two weeks after surgery and decalcified samples were processed for Bone-To-Implant Contact (BIC) and Bone Area Density (BAD) measurements. Analysis of variance (ANOVA) was used for statistical evaluation. P<0.05 was considered to be significant. Ovariectomy induced statistically significant lower BAD values (p=0.008) and a tendency towards lower BIC values when compared osteoporotic and healthy groups. The administration of 4 ?g of IGF-I did not produce statistically significant differences neither on BIC nor on BAD values, neither in the osteoporotic animals nor in healthy. Within the limitations of this experimental study, local administration of 4 ?g of IGF-I was not able to induce any changes in the osseointegration process two weeks after surgery, neither in healthy rabbits nor in the osteoporotic group. es
dc.title Effects of locally applied Insulin-like Growth Factor-I on osseointegration es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.22973 es
dc.type.hasVersion VoR es_ES

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