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Validation of microRNA expression profile in Oral Lichenoid Disease through cytological samples

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Validation of microRNA expression profile in Oral Lichenoid Disease through cytological samples

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dc.contributor.author Setién Olarra, Amaia es
dc.contributor.author Marichalar Mendia, Xabier es
dc.contributor.author Fernández-Pacheco, Juan-Alonso es
dc.contributor.author Fernández-Barriales-López, Marcos es
dc.contributor.author Gainza Cirauqui, María Luisa es
dc.contributor.author Aguirre Urízar, José Manuel es
dc.date.accessioned 2019-11-06T12:51:54Z
dc.date.available 2019-11-06T12:51:54Z
dc.date.issued 2019 es
dc.identifier.citation Setién Olarra, Amaia ; Marichalar Mendia, Xabier ; Fernández-Pacheco, Juan-Alonso ; Fernández-Barriales-López, Marcos ; Gainza Cirauqui, María Luisa ; Aguirre Urízar, José Manuel. Validation of microRNA expression profile in Oral Lichenoid Disease through cytological samples. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 24 5 2019: 13- es
dc.identifier.uri https://hdl.handle.net/10550/72071
dc.description.abstract To validate oral exfoliative cytology in the analysis of the microRNA expression profile in Oral Lichenoid Disease (OLD). The expression of 13 microRNAs identified and presented by our group in a previous study was analyzed in 26 cases, 16 diagnosed as OLD and 10 controls with no oral mucosal pathology. Cytological samples from the oral mucosa obtained using an Orcellex toothbrush were analyzed using RT-qPCR and TaqMan microRNA assays. The aberrant expression was validated for 2 microRNAs (miR-146a-5p and miR-7-1-3p) of those previously recognized in the biopsy study. This is the first time that oral exfoliative cytology is validated in a study of the alterations of the expression of microRNAs in OLD. The alteration of miR-146a and miR-7 compared to controls was validated. These microRNAs are associated with both inflammatory and carcinogenic phenomena that are involved in the etiopathogenesis of this potentially malignant oral disorder. es
dc.title Validation of microRNA expression profile in Oral Lichenoid Disease through cytological samples es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.23020 es
dc.type.hasVersion VoR es_ES

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