Purpose. Alveolar osteitis is the most common post-odontectomy complication. Although blood clot disintegration is known to be the cause of the condition, an agreement is lacking regarding a treatment of choice. The aim of the current study therefore was to evaluate major autohemotherapy as one treatment method. Patients and Methods. A total of 183 patients were categorized into 4 groups (I, II, III, and IV) according to pain severity (mild, moderate, severe, or agonizing, respectively). Major autohemotherapy was performed for all patients by withdrawing 225mL of patient's blood and mixing them with 225mL of Oxygen-Ozone gas (where Ozone concentration was 50µg/mL gas) Results and Discussion. Despite AHT was a high-potency curative treatment for groups I and II, it was palliative for group IV. For group III, it oscillated between being a curative or a palliative treatment with a statistically insignificant difference. Conclusion. AHT might be a recommended treatment for AO