NAGIOS: RODERIC FUNCIONANDO

Bax transmembrane domain interacts with prosurvival Bcl-2 proteins in biological membranes

Repositori DSpace/Manakin

IMPORTANT: Aquest repositori està en una versió antiga des del 3/12/2023. La nova instal.lació está en https://roderic.uv.es/

Bax transmembrane domain interacts with prosurvival Bcl-2 proteins in biological membranes

dc.contributor.author	Andreu Fernández,Vicente
dc.contributor.author	Sancho, Mónica
dc.contributor.author	Genovés, Ainhoa
dc.contributor.author	Lucendo, Estefanía
dc.contributor.author	Todt, Franziska
dc.contributor.author	Lauterwasser, Joachim
dc.contributor.author	Funk, Kathrin
dc.contributor.author	Jahreis, Günther
dc.contributor.author	Pérez Payá, Enrique
dc.contributor.author	Mingarro Muñoz, Ismael
dc.contributor.author	Edlich, Frank
dc.contributor.author	Orzáez Calatayud, María del Mar
dc.date.accessioned	2019-11-12T12:02:02Z
dc.date.available	2019-11-12T12:02:02Z
dc.date.issued	2017
dc.identifier.citation	Andreu Fernández,Vicente Sancho, Mónica Genovés, Ainhoa Lucendo, Estefanía Todt, Franziska Lauterwasser, Joachim Funk, Kathrin Jahreis, Günther Pérez Payá, Enrique Mingarro Muñoz, Ismael Edlich, Frank Orzáez Calatayud, María del Mar 2017 Bax transmembrane domain interacts with prosurvival Bcl-2 proteins in biological membranes Proceedings of the National Academy of Sciences of the United States of America 114 2 310 315
dc.identifier.uri	https://hdl.handle.net/10550/72177
dc.description.abstract	The Bcl-2 (B-cell lymphoma 2) protein Bax (Bcl-2 associated X, apoptosis regulator) can commit cells to apoptosis via outer mitochondrial membrane permeabilization. Bax activity is controlled in healthy cells by prosurvival Bcl-2 proteins. C-terminal Bax transmembrane domain interactions were implicated recently in Bax pore formation. Here, we show that the isolated transmembrane domains of Bax, Bcl-xL (B-cell lymphoma-extra large), and Bcl-2 can mediate interactions between Bax and prosurvival proteins inside the membrane in the absence of apoptotic stimuli. Bcl-2 protein transmembrane domains specifically homooligomerize and heterooligomerize in bacterial and mitochondrial membranes. Their interactions participate in the regulation of Bcl-2 proteins, thus modulating apoptotic activity. Our results suggest that interactions between the transmembrane domains of Bax and antiapoptotic Bcl-2 proteins represent a previously unappreciated level of apoptosis regulation.
dc.language.iso	eng
dc.relation.ispartof	Proceedings of the National Academy of Sciences of the United States of America, 2017, vol. 114, num. 2, p. 310-315
dc.subject	Biotecnologia
dc.subject	Proteïnes
dc.subject	Membranes (Biologia)
dc.title	Bax transmembrane domain interacts with prosurvival Bcl-2 proteins in biological membranes
dc.type	journal article	es_ES
dc.date.updated	2019-11-12T12:02:03Z
dc.identifier.doi	10.1073/pnas.1612322114
dc.identifier.idgrec	116625
dc.rights.accessRights	open access	es_ES