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Homochiral Metal-Organic Frameworks for Enantioselective Separations in Liquid Chromatography

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Homochiral Metal-Organic Frameworks for Enantioselective Separations in Liquid Chromatography

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dc.contributor.author	Corella-Ochoa, M. Nieves
dc.contributor.author	Tapia, Jesús B.
dc.contributor.author	Rubin, Heather N.
dc.contributor.author	Lillo, Vanesa
dc.contributor.author	González-Cobos, Jesús
dc.contributor.author	Núñez-Rico, J. L.
dc.contributor.author	Balestra, Salvador R. G.
dc.contributor.author	Almora-Barrios, Neyvis
dc.contributor.author	Lledós, Marina
dc.contributor.author	Güell-Bara, Arnau
dc.contributor.author	Cabezas-Giménez, Juanjo
dc.contributor.author	Escudero-Adán, Eduardo
dc.contributor.author	Vidal-Ferran, Anton
dc.contributor.author	Calero, Sofía
dc.contributor.author	Reynolds, Melissa
dc.contributor.author	Martí Gastaldo, Carlos
dc.contributor.author	Galán Mascarós, José Ramón
dc.date.accessioned	2019-11-13T15:10:49Z
dc.date.available	2019-11-19T05:45:05Z
dc.date.issued	2019
dc.identifier.citation	Corella-Ochoa, M. Nieves Tapia, Jesús B. Rubin, Heather N. Lillo, Vanesa González-Cobos, Jesús Núñez-Rico, J. L. Balestra, Salvador R. G. Almora-Barrios, Neyvis Lledós, Marina Güell-Bara, Arnau Cabezas-Giménez, Juanjo Escudero-Adán, Eduardo Vidal-Ferran, Anton Calero, Sofía Reynolds, Melissa Martí Gastaldo, Carlos Galán Mascarós, José Ramón 2019 Homochiral Metal-Organic Frameworks for Enantioselective Separations in Liquid Chromatography Journal of the American Chemical Society 141 36 14306 14316
dc.identifier.uri	https://hdl.handle.net/10550/72194
dc.description.abstract	Selective separation of enantiomers is a substantial challenge for the pharmaceutical industry. Chromatography on chiral stationary phases is the standard method, but at a very high cost for industrial-scale purification owing to the high cost of the chiral stationary phases. Typically, these materials are poorly robust, expensive to manufacture and often too specific for a single desired substrate, lacking desirable versatility across different chiral analytes. Here we disclose a porous, robust homochiral metal-organic framework (MOF), TAMOF-1, built from copper(II) and an affordable linker prepared from natural L-histidine. TAMOF-1 has shown to be able to separate a variety of model racemic mixtures, including drugs, in a wide range of solvents of different polarity, outperforming several commercial chiral columns for HPLC separations. Although not exploited in the present article, it is worthy to mention that the preparation of this new material is scalable to the multikilogram scale, opening unprecedented possibilities for low-energy chiral separation at the industrial scale.
dc.language.iso	eng
dc.relation.ispartof	Journal of the American Chemical Society, 2019, vol. 141, num. 36, p. 14306-14316
dc.subject	Química organometàl·lica
dc.title	Homochiral Metal-Organic Frameworks for Enantioselective Separations in Liquid Chromatography
dc.type	journal article	es_ES
dc.date.updated	2019-11-13T15:10:49Z
dc.identifier.doi	10.1021/jacs.9b06500
dc.identifier.idgrec	135126
dc.accrualmethod
dc.embargo.terms	1 year
dc.rights.accessRights	open access	es_ES