Calcification between the anterior and posterior clinoid processes, also the so-called sella turcica bridging, has been associated in some studies with skeletal anomalies as well as with dental and eruption disturbances. It was hypothesized that sella turcica bridging was associated with an altered direction of dental eruption. The aim of the study was to assess whether there was a relationship between the degree of calcification and the presence or absence of an alteration in the tooth eruption direction. A case-control multicenter study was conducted. The study population consisted of 150 subjects (age 10-50 years), 30 of which presented some type of alteration of the direction canine eruption (impactation or transposition) (cases) and 120 selected at random who did not present altered direction of dental eruption (controls). Cases and controls were matched by age, sex, and approximate date of starting orthodontic treatment. Lateral cephalometric radiographies were obtained and the extent of the sella turcica bridging was measured using a Vernier caliper and scored as no calcification, partially calcified, and completely calcified. The frequency of a partially or completely calcified sella turcica bridge was significantly higher among cases with altered direction of dental eruption as compared with controls. There was a trend towards a shorter length of sella turcica in subjects with two or more canine eruption alterations. Sella turcica bridging was unrelated to sex, but it was significantly influenced by age. Sella turcica bridging is frequently detected in subjects with altered direction of dental eruption of canines.