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Resonancia Magnetica Funcional con Paradigma Auditivo Emocional en Pacientes con un Primer Episodio Psicótico

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Resonancia Magnetica Funcional con Paradigma Auditivo Emocional en Pacientes con un Primer Episodio Psicótico

dc.contributor.advisor	Sanjuán Arias, Julio
dc.contributor.advisor	García Martí, Gracián
dc.contributor.advisor	Espert Tortajada, Raúl
dc.contributor.author	Soldevila Matías, Pablo
dc.contributor.other	Departament de Psicobiologia	es_ES
dc.date.accessioned	2019-12-04T10:29:21Z
dc.date.available	2019-12-05T05:45:06Z
dc.date.issued	2019	es_ES
dc.date.submitted	28-11-2019	es_ES
dc.identifier.uri	https://hdl.handle.net/10550/72375
dc.description.abstract	Neuroimaging studies of emotional response in patients with Psychosis have mainly used visual stimuli, i.e., still photographs of emotional faces paradigms and shown globally reduced brain activity. Much less is known about the mechanisms underlying emotion recognition deficits within the auditory modality. Our principal aim is to evaluate the emotional response of First-Episode Psychotic (FEP) patients to neutral and emotional words. An auditory emotional paradigm based on the most frequent words heard by psychotic patients with auditory hallucinations was designed. This paradigm was applied to evaluate cerebral activation with functional magnetic resonance imaging (fMRI) in 59 FEP patients and 50 healthy subjects. We found a clear enhanced activity of the frontal lobe, temporal cortex, cingulate and mainly hippocampus and amygdala in patients when hearing emotional words in comparison with controls. Our findings are consistent with other studies suggesting a significant role for emotional response, revealing that alterations in limbic system are present in the early stages of psychosis, and these alterations are correlated with the severity of the illness.	es_ES
dc.format.extent	209 p.	es_ES
dc.language.iso	en	es_ES
dc.subject	neurociencia	es_ES
dc.subject	psicosis	es_ES
dc.subject	paradigma emocional	es_ES
dc.title	Resonancia Magnetica Funcional con Paradigma Auditivo Emocional en Pacientes con un Primer Episodio Psicótico	es_ES
dc.type	doctoral thesis	es_ES
dc.subject.unesco	UNESCO::PSICOLOGÍA	es_ES
dc.subject.unesco	UNESCO::CIENCIAS MÉDICAS ::Ciencias clínicas::Psicología clínica	es_ES
dc.embargo.terms	0 days	es_ES