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Urinary metals and metal mixtures and oxidative stress biomarkers in an adult population from Spain: The Hortega Study

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Urinary metals and metal mixtures and oxidative stress biomarkers in an adult population from Spain: The Hortega Study

dc.contributor.author	Domingo-Relloso, A
dc.contributor.author	Grau Pérez, María
dc.contributor.author	Galan Chilet, Inmaculada
dc.contributor.author	Garrido-Martinez, M.J.
dc.contributor.author	Tormos, Carmen
dc.contributor.author	Navas-Acien, Ana
dc.contributor.author	Gómez-Ariza, José LuisL
dc.contributor.author	Monzó-Beltran, Lidia
dc.contributor.author	Sáez Tormo, Guillermo
dc.contributor.author	Garcia-Barrera, Tamara
dc.contributor.author	Dueñas Laita, Antonio
dc.contributor.author	Briongos Figuero, Laisa S
dc.contributor.author	Martin-Escudero, Juan C.
dc.contributor.author	Chaves Martínez, Felipe Javier
dc.contributor.author	Redón i Más, Josep
dc.contributor.author	Téllez-Plaza, María
dc.date.accessioned	2020-01-31T09:20:53Z
dc.date.available	2020-01-31T09:20:53Z
dc.date.issued	2019
dc.identifier.citation	Domingo-Relloso, A Grau Pérez, María Galan Chilet, Inmaculada Garrido-Martinez, M.J. Tormos, Carmen Navas-Acien, Ana Gómez-Ariza, José LuisL Monzó-Beltran, Lidia Sáez Tormo, Guillermo Garcia-Barrera, Tamara Dueñas Laita, Antonio Briongos Figuero, Laisa S Martin-Escudero, Juan C. Chaves Martinez, Felipe Javier Redón, Josep Tellez-Plaza, Maria 2019 Urinary metals and metal mixtures and oxidative stress biomarkers in an adult population from Spain: The Hortega Study Environment International 123 171 180
dc.identifier.uri	https://hdl.handle.net/10550/72794
dc.description.abstract	INTRODUCTION: Few studies have investigated the role of exposure to metals and metal mixtures on oxidative stress in the general population. OBJECTIVES: We evaluated the cross-sectional association of urinary metal and metal mixtures with urinary oxidative stress biomarkers, including oxidized to reduced glutathione ratio (GSSG/GSH), malondialdehyde (MDA), and 8‑oxo‑7,8‑dihydroguanine (8-oxo-dG), in a representative sample of a general population from Spain (Hortega Study). METHODS: Urine antimony (Sb), barium (Ba), cadmium (Cd), chromium (Cr), cobalt (Co), copper (Cu), molybdenum (Mo), vanadium (V) and zinc (Zn) were measured by ICPMS in 1440 Hortega Study participants. RESULTS: The geometric mean ratios (GMRs) of GSSG/GSH comparing the 80th to the 20th percentiles of metal distributions were 1.15 (95% confidence intervals [95% CI]: 1.03-1.27) for Mo, 1.17 (1.05-1.31) for Ba, 1.23 (1.04-1.46) for Cr and 1.18 (1.00-1.40) for V. For MDA, the corresponding GMRs (95% CI) were 1.13 (1.03-1.24) for Zn and 1.12 (1.02-1.23) for Cd. In 8-oxo-dG models, the corresponding GMR (95% CI) were 1.12 (1.01-1.23) for Zn and 1.09 (0.99-1.20) for Cd. Cr for GSSG/GSH and Zn for MDA and 8-oxo-dG drove most of the observed associations. Principal component (PC) 1 (largely reflecting non-essential metals) was positively associated with GSSG/GSH. The association of PC2 (largely reflecting essential metals) was positive for GSSG/GSH but inverse for MDA. CONCLUSIONS: Urine Ba, Cd, Cr, Mo, V and Zn were positively associated with oxidative stress measures at metal exposure levels relevant for the general population. The potential health consequences of environmental, including nutritional, exposure to these metals warrants further investigation.
dc.language.iso	cat
dc.relation.ispartof	Environment International, 2019, vol. 123, p. 171-180
dc.title	Urinary metals and metal mixtures and oxidative stress biomarkers in an adult population from Spain: The Hortega Study
dc.type	journal article	es_ES
dc.date.updated	2020-01-31T09:20:53Z
dc.identifier.doi	10.1016/j.envint.2018.11.055
dc.identifier.idgrec	130951
dc.rights.accessRights	open access	es_ES