This study quantifies morphological evolution of the Dez River, Iran, from 1955 to 2016. The approach uses a sequence of Landsat images, aerial photos, and topographic maps. In addition, the hydrological data including average daily discharge and yearly maximum discharge at the Dezful hydrological station for the period (1955-2016) were used. The study reach was divided into 48 meander loops from upstream to downstream. Active channel width (w) was determined at 10 m intervals and changes assessed along the study reach of the Dez River. Morphological indices including sinuosity index; straight meander length; centerline flow length; erosion area; erodible length channel migration; centerline elongation; and radius of curvature were calculated in the reach. Results showed that the study reach of the Dez River changed dramatically in response to major floods, although the general trend is towards a narrowing of active channel width by 38% in the period 1955-2016. Results show that most of the meander loops in the study area extended and expanded. Between 1989 and 1995, all types of meander change were observed. There was a direct correlation between the frequency of hydrological events (flood days) bigger than 2-years return period and elongation of bends.