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Salivary Cytokines in patients with Head and Neck Cancer (HNC) treated with Radiotherapy

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Salivary Cytokines in patients with Head and Neck Cancer (HNC) treated with Radiotherapy

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dc.contributor.author Principe, Sara es
dc.contributor.author Dikova, Valentina R. es
dc.contributor.author Bagán Sebastián, José Vicente es
dc.date.accessioned 2020-02-04T13:25:53Z
dc.date.available 2020-02-04T13:25:53Z
dc.date.issued 2019 es
dc.identifier.citation Principe, Sara ; Dikova, Valentina R. ; Bagán Sebastián, José Vicente. Salivary Cytokines in patients with Head and Neck Cancer (HNC) treated with Radiotherapy. En: Journal of Clinical and Experimental Dentistry, 11 11 2019: 1072-1077 es
dc.identifier.uri https://hdl.handle.net/10550/72878
dc.description.abstract Head and Neck cancer (HNC) is the sixth most common cancer in the world. The 5-year survival rate depends on early diagnosis and appropriate therapy. Typically, late diagnosis requires not only surgical intervention, but also radiotherapy treatment combined or not with chemotherapy. Ionizing radiation is known to increase the expression of a number of cytokines involved in inflammation, wound healing and toxicity areas. Salivary cytokines have promising features to be used as biomarkers for disease screening and outcome prediction in this malignancy. The aim of this article is to analyze the role of salivary inflammatory response elements in HNC patients treated with radiotherapy, their modulation and association with the treatment outcome. A bibliographical search was performed on Pubmed, Cochrane and Embase using the following keywords: cytokines, saliva, head and neck cancer, radiotherapy. The cut-off point for the research were scientific papers published over the last 10 years. After a two-step selection process, 15 articles were identified and subjected to review. Radiotherapy treatment was shown to influence a number of salivary cytokines. A trend towards a growth of IL-1?, IL-6, IL-8, MCP-1, and TNF-? levels was observed and it correlated with the irradiation dose. The analysis of salivary cytokines could be a useful biomarker for predicting radiotherapy outcome in HNC. However, large-scale investigations are required to validate the use of these cytokines in predicting and diagnosing HNC, as well as evaluating the response to the treatment. es
dc.title Salivary Cytokines in patients with Head and Neck Cancer (HNC) treated with Radiotherapy es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/jced.56318 es
dc.type.hasVersion VoR es_ES

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