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Effect of milk based fruit beverage enriched with plant sterols and/or galactooligosaccharides in a murine chronic colitis model

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Effect of milk based fruit beverage enriched with plant sterols and/or galactooligosaccharides in a murine chronic colitis model

dc.contributor.author	López-García, Gabriel
dc.contributor.author	Cilla Tatay, Antonio
dc.contributor.author	Barberá Sáez, Reyes
dc.contributor.author	Alegría Torán, Amparo Asunción
dc.contributor.author	Recio, María C.
dc.date.accessioned	2020-03-25T13:25:33Z
dc.date.available	2020-03-25T13:25:33Z
dc.date.issued	2019
dc.identifier.citation	López-García, Gabriel Cilla Tatay, Antonio Barberá Sáez, Reyes Alegría Torán, Amparo Asunción Recio, María C. 2019 Effect of milk based fruit beverage enriched with plant sterols and/or galactooligosaccharides in a murine chronic colitis model Foods
dc.identifier.uri	https://hdl.handle.net/10550/73659
dc.description.abstract	The potential anti-inflammatory effect of plant sterols (PS) enriched milk-based fruit beverages (PS, 1 g/100 mL) (MfB) with/without galactooligosaccharides (GOS, 2 g/100 mL) (MfB-G) in an experimental mice model of chronic ulcerative colitis was evaluated. Beverages were orally administered to mice every day by gavage to achieve PS and GOS doses of 35 and 90 mg/kg, respectively, and experimental colitis was induced by giving mice drinking water ad libitum containing 2% (w/v) dextran sulphate sodium (DSS) for 7 days, alternating with periods without DSS up to the end of the study (56 days). MfB beverage showed significant reduction of symptoms associated to ulcerative colitis and improved the colon shortening and mucosal colonic damage, but it was not able to reduce the increase of myeloperoxidase levels produced by DSS. MfB-G showed higher incidence of bloody feces and loss of stool consistency than MfB, as well as high levels of immune cells infiltration in colon tissue and myeloperoxidase. Therefore, PS-enriched milk-based fruit beverage could be an interesting healthy food to extend the remission periods of the diseases and the need to evaluate, in a pre-clinical model, the anti-inflammatory effect of the combination of bioactive compounds in the context of a whole food matrix.
dc.language.iso	eng
dc.relation.ispartof	Foods, 2019
dc.subject	Tracte gastrointestinal Malalties
dc.title	Effect of milk based fruit beverage enriched with plant sterols and/or galactooligosaccharides in a murine chronic colitis model
dc.type	journal article	es_ES
dc.date.updated	2020-03-25T13:25:33Z
dc.identifier.doi	10.3990/foods8040114
dc.identifier.idgrec	135834
dc.rights.accessRights	open access	es_ES