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Organocatalytic Enantioselective Aminoalkylation of Pyrazol-3-ones with Aldimines Generated in Situ from α‐Amido Sulfones

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Organocatalytic Enantioselective Aminoalkylation of Pyrazol-3-ones with Aldimines Generated in Situ from α‐Amido Sulfones

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dc.contributor.author	Carceller-Ferrer, Laura
dc.contributor.author	Vila Descals, Carlos
dc.contributor.author	Blay Llinares, Gonzalo
dc.contributor.author	Fernández Picot, Isabel
dc.contributor.author	Muñoz, M. Carmen
dc.contributor.author	Pedro, José Ramón
dc.date.accessioned	2020-03-26T12:04:22Z
dc.date.available	2020-11-06T05:45:05Z
dc.date.issued	2019
dc.identifier.citation	Carceller-Ferrer, Laura Vila Descals, Carlos Blay Llinares, Gonzalo Fernández Picot, Isabel Muñoz, M. Carmen Pedro, José Ramón 2019 Organocatalytic Enantioselective Aminoalkylation of Pyrazol-3-ones with Aldimines Generated in Situ from α‐Amido Sulfones Organic & Biomolecular Chemistry 17 46 9859 9863
dc.identifier.uri	https://hdl.handle.net/10550/73671
dc.description.abstract	Herein, an efficient asymmetric aminoalkylation of pyrazolones with α-amido sulfones catalyzed by a quinine-derived squaramide in dichloromethane/aqueous media has been established. A variety of chiral amines were obtained with high yields (up to 98%) and excellent enantioselectivities (up to 99% ee). The corresponding products are transformed into optically active acetylated pyrazoles after treatment with Ac2O/Et3N, because of the instability of some adducts. The reaction tolerates a wide range of α-amido sulfones and different pyrazolones.
dc.language.iso	eng
dc.relation.ispartof	Organic & Biomolecular Chemistry, 2019, vol. 17, num. 46, p. 9859-9863
dc.subject	Química orgànica
dc.subject	Catàlisi
dc.title	Organocatalytic Enantioselective Aminoalkylation of Pyrazol-3-ones with Aldimines Generated in Situ from α‐Amido Sulfones
dc.type	journal article	es_ES
dc.date.updated	2020-03-26T12:04:22Z
dc.identifier.doi	10.1039/C9OB02252J
dc.identifier.idgrec	135253
dc.embargo.terms	1 year
dc.rights.accessRights	open access	es_ES