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Organocatalytic Enantioselective Functionalization of Hydroxyquinolines through an aza-Friedel-Crafts Alkylation with Isatin-derived Ketimines

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Organocatalytic Enantioselective Functionalization of Hydroxyquinolines through an aza-Friedel-Crafts Alkylation with Isatin-derived Ketimines

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dc.contributor.author	Vila Descals, Carlos
dc.contributor.author	Rendón-Patiño, Alejandra
dc.contributor.author	Montesinos Magraner, Marc
dc.contributor.author	Blay Llinares, Gonzalo
dc.contributor.author	Muñoz, M. Carmen
dc.contributor.author	Pedro, José Ramón
dc.date.accessioned	2020-03-27T10:18:22Z
dc.date.available	2020-03-27T10:18:22Z
dc.date.issued	2018
dc.identifier.citation	Vila Descals, Carlos Rendón-Patiño, Alejandra Montesinos Magraner, Marc Blay Llinares, Gonzalo Muñoz, M. Carmen Pedro, José Ramón 2018 Organocatalytic Enantioselective Functionalization of Hydroxyquinolines through an aza-Friedel-Crafts Alkylation with Isatin-derived Ketimines Advanced Synthesis & Catalysis 360 5 859 864
dc.identifier.uri	https://hdl.handle.net/10550/73683
dc.description.abstract	A highly enantioselective addition o hydroxyquinolines to isatin-derived ketimines hasbeen realized using a quinine-derived thiourea organocatalyst. The reaction affords chiral 3-amino-2-oxindoles bearing a quinoline moiety with a quaternary stereocenter in high yields (up to 98%) and excellent enantioselectivities (up to 99%). Moreover, we can extend this methodology for the enantioselective functionalization of 5-hydroxyisoquinoline. This methodology represents, to the best of our knowledge, the first enantioselective addition of hydroxyquinolines to imines.
dc.language.iso	eng
dc.relation.ispartof	Advanced Synthesis & Catalysis, 2018, vol. 360, num. 5, p. 859-864
dc.subject	Reaccions químiques
dc.subject	Catàlisi
dc.title	Organocatalytic Enantioselective Functionalization of Hydroxyquinolines through an aza-Friedel-Crafts Alkylation with Isatin-derived Ketimines
dc.type	journal article	es_ES
dc.date.updated	2020-03-27T10:18:22Z
dc.identifier.doi	10.1002/adsc.201701217
dc.identifier.idgrec	121641
dc.rights.accessRights	open access	es_ES