NAGIOS: RODERIC FUNCIONANDO

Regio‐, Diastereo‐, and Enantioselective Organocatalytic Addition of 4‐Substituted Pyrazolones to Isatin‐Derived Nitroalkenes

Repositori DSpace/Manakin

Valencià Castellano

Inici
Investigació
e-prints
23 - Química
Visualitza element

IMPORTANT: Aquest repositori està en una versió antiga des del 3/12/2023. La nova instal.lació está en https://roderic.uv.es/

Regio‐, Diastereo‐, and Enantioselective Organocatalytic Addition of 4‐Substituted Pyrazolones to Isatin‐Derived Nitroalkenes

Mostra el registre parcial de l'element

dc.contributor.author	Vila Descals, Carlos
dc.contributor.author	Dharmaraj, Nisshanth Raj
dc.contributor.author	Faubel, Antonio
dc.contributor.author	Blay Llinares, Gonzalo
dc.contributor.author	Cardona Prósper, María Luz
dc.contributor.author	Muñoz, M. Carmen
dc.contributor.author	Pedro, José Ramón
dc.date.accessioned	2020-04-06T08:17:30Z
dc.date.available	2020-04-06T08:17:30Z
dc.date.issued	2019
dc.identifier.citation	Vila Descals, Carlos Dharmaraj, Nisshanth Raj Faubel, Antonio Blay Llinares, Gonzalo Cardona Prósper, María Luz Muñoz, M. Carmen Pedro, José Ramón 2019 Regio‐, Diastereo‐, and Enantioselective Organocatalytic Addition of 4‐Substituted Pyrazolones to Isatin‐Derived Nitroalkenes European Journal of Organic Chemistry 2019 19 3040 3044
dc.identifier.uri	https://hdl.handle.net/10550/73776
dc.description.abstract	Hydroquinine 2,5‐diphenyl‐4,6‐pyrimidinediyl diether [(DHQ)2Pyr] catalyzed the regio‐, diastereo‐, and enantioselective addition of 4‐substituted pyrazolones to isatin‐derived nitroalkenes, providing a variety of chiral alkenylpyrazolone adducts containing a tetrasubstituted stereocenter bearing an oxindole moiety with excellent yields, regioselectivity, and diastereoselectivity, as well as a moderate enantioselectivity (up to 98 % yield, > 20:1 E/Z ratio dr and 78 % ee). The reaction harnesses a nitroalkene as an alkenylating agent through a Nucleophilic Vinylic Substitution (SNV) reaction.
dc.language.iso	eng
dc.relation.ispartof	European Journal of Organic Chemistry, 2019, vol. 2019, num. 19, p. 3040-3044
dc.subject	Química orgànica
dc.subject	Catàlisi
dc.title	Regio‐, Diastereo‐, and Enantioselective Organocatalytic Addition of 4‐Substituted Pyrazolones to Isatin‐Derived Nitroalkenes
dc.type	journal article	es_ES
dc.date.updated	2020-04-06T08:17:31Z
dc.identifier.doi	10.1002/ejoc.201900328
dc.identifier.idgrec	133111
dc.rights.accessRights	open access	es_ES