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Changes in Chemokines and Chemokine Receptors Expression in a Mouse Model of Alzheimer's Disease

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Changes in Chemokines and Chemokine Receptors Expression in a Mouse Model of Alzheimer's Disease

dc.contributor.author	Jordá Vallés, Adrián
dc.contributor.author	Cauli, Omar
dc.contributor.author	Santonja, José M
dc.contributor.author	Aldasoro Celaya, Martín
dc.contributor.author	Aldasoro, Constanza
dc.contributor.author	Obrador Plá, Elena
dc.contributor.author	Vila Salinas, José María
dc.contributor.author	Mauricio Aviñó, María Dolores
dc.contributor.author	Iradi Casal, Antonio
dc.contributor.author	Guerra Ojeda, Sol
dc.contributor.author	Marchio, Patricia
dc.contributor.author	Vallés Martí, Lilián Soraya
dc.date.accessioned	2020-04-21T08:51:46Z
dc.date.available	2020-04-21T08:51:46Z
dc.date.issued	2019
dc.identifier.citation	Jordá Vallés, Adrián Cauli, Omar Santonja, José M Aldasoro Celaya, Martín Aldasoro, Constanza Obrador Plá, Elena Vila Salinas, José María Mauricio Aviñó, María Dolores Iradi Casal, Antonio Guerra Ojeda, Sol Marchio, Patricia Vallés Martí, Lilián Soraya 2019 Changes in Chemokines and Chemokine Receptors Expression in a Mouse Model of Alzheimer's Disease. Int J Biol Sci. 2019 Jan 1;15(2):453-463. doi: 10.7150/ijbs.26703. eCollection 2019. PMID: 30745834 International Journal Of Biological Sciences 15 2 453 463
dc.identifier.uri	https://hdl.handle.net/10550/73942
dc.description.abstract	The amyloid precursor protein plus presenilin-1 (APP/PS1) mice are a frequently-used model for Alzheimer's disease studies (AD). However, the data relevant to which proteins are involved in inflammatory mechanism are not sufficiently well-studied using the AD mouse model. Using behavioral studies, quantitative RT-PCR and Western-blot techniques, significant findings were determined by the expression of proteins involved in inflammation comparing APP/PS1 and Wild type mice. Increased GFAP expression could be associated with the elevation in number of reactive astrocytes. IL-3 is involved in inflammation and ABDF1 intervenes normally in the transport across cell membranes and both were found up-regulated in APP/PS1 mice compared to Wild type mice. Furthermore, CCR5 expression was decreased and both CCL3 and CCL4 chemokines were highly expressed indicating a possible gliosis and probably an increase in chemotaxis from lymphocytes and T cell generation. We also noted for the first time, a CCR8 increase expression with diminution of its CCL1 chemokine, both normally involved in protection from bacterial infection and demyelination. Control of inflammatory proteins will be the next step in understanding the progression of AD and also in determining the mechanisms that can develop in this disease.
dc.language.iso	cat
dc.relation.ispartof	International Journal Of Biological Sciences, 2019, vol. 15, num. 2, p. 453-463
dc.title	Changes in Chemokines and Chemokine Receptors Expression in a Mouse Model of Alzheimer's Disease
dc.type	journal article	es_ES
dc.date.updated	2020-04-21T08:51:47Z
dc.identifier.doi	10.7150/ijbs.26703
dc.identifier.idgrec	131937
dc.rights.accessRights	open access	es_ES