NAGIOS: RODERIC FUNCIONANDO

Cubic Microcontainers Improve In Situ Colonic Mucoadhesion and Absorption of Amoxicillin in Rats

Repositori DSpace/Manakin

IMPORTANT: Aquest repositori està en una versió antiga des del 3/12/2023. La nova instal.lació está en https://roderic.uv.es/

Cubic Microcontainers Improve In Situ Colonic Mucoadhesion and Absorption of Amoxicillin in Rats

dc.contributor.author	Christfort, Juliane F.
dc.contributor.author	Guillot García, Antonio José
dc.contributor.author	Melero Zaera, Ana
dc.contributor.author	Thamdrup, Lasse H. E.
dc.contributor.author	Garrigues Pelufo, Teresa María
dc.contributor.author	Boisen, Anja
dc.contributor.author	Zór, Kinga
dc.contributor.author	Nielsen, Line H.
dc.date.accessioned	2020-05-15T09:22:06Z
dc.date.available	2020-05-15T09:22:06Z
dc.date.issued	2020
dc.identifier.citation	Christfort, Juliane F. Guillot García, Antonio José Melero Zaera, Ana Thamdrup, Lasse H. E. Garrigues Pelufo, Teresa María Boisen, Anja Zór, Kinga Nielsen, Line H. 2020 Cubic Microcontainers Improve In Situ Colonic Mucoadhesion and Absorption of Amoxicillin in Rats Pharmaceutics 12 355
dc.identifier.uri	https://hdl.handle.net/10550/74624
dc.description.abstract	An increased interest in colonic drug delivery has led to a higher focus on the design of delivery devices targeting this part of the gastrointestinal tract. Microcontainers have previously facilitated an increase in oral bioavailability of drugs. The surface texture and shape of microcontainers have proven to influence the mucoadhesion ex vivo. In the present work, these findings were further investigated using an in situ closed-loop perfusion technique in the rat colon, which allowed for simultaneous evaluation of mucoadhesion of the microcontainers as well as drug absorption. Cylindrical, triangular and cubic microcontainers, with the same exterior surface area, were evaluated based on in vitro release, in situ mucoadhesion and in situ absorption of amoxicillin. Additionally, the mucoadhesion of empty cylindrical microcontainers with and without pillars on the top surface was investigated. From the microscopy analysis of the colon sections after the in situ study, it was evident that a significantly higher percentage of cubic microcontainers than cylindrical microcontainers adhered to the intestinal mucus. Furthermore, the absorption rate constants and blood samples indicated that amoxicillin in cubic microcontainers was absorbed more readily than when cylindrical or triangular microcontainers were dosed. This could be due to a higher degree of mucoadhesion for these particular microcontainers.
dc.language.iso	eng
dc.relation.ispartof	Pharmaceutics, 2020, vol. 12, num. 355
dc.subject	Drogues
dc.subject	Absorció intestinal
dc.subject	Tecnologia farmacèutica
dc.title	Cubic Microcontainers Improve In Situ Colonic Mucoadhesion and Absorption of Amoxicillin in Rats
dc.type	journal article	es_ES
dc.date.updated	2020-05-15T09:22:06Z
dc.identifier.doi	10.3390/pharmaceutics12040355
dc.identifier.idgrec	138115
dc.rights.accessRights	open access	es_ES