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Function of Glia in Aging and the Brain Diseases

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Function of Glia in Aging and the Brain Diseases

dc.contributor.author	Vallés Martí, Lilián Soraya
dc.contributor.author	Iradi, Antonio
dc.contributor.author	Aldasoro Celaya, Martín
dc.contributor.author	Vila, José María
dc.contributor.author	Aldasoro, Constanza
dc.contributor.author	de la Torre, Jack
dc.contributor.author	Campos Campos, Juan
dc.contributor.author	Jorda, Adrian
dc.date.accessioned	2020-05-25T10:21:38Z
dc.date.available	2020-05-25T10:21:38Z
dc.date.issued	2019
dc.identifier.citation	Vallés Martí, Lílian Soraya Antonio Iradi Martin Aldasoro Jose M. Vila Constanza Aldasoro Jack de la Torre Juan Campos-Campos Adrian Jorda. 2019 Function of Glia in Aging and the Brain Diseases. International Journal Of Medical Sciences 16 11 1473 1479
dc.identifier.uri	https://hdl.handle.net/10550/74712
dc.description.abstract	Microglia cells during aging, neurodegeneration and neuroinflammation show different morphological and transcriptional profiles (related to axonal direction and cell adhesion). Furthermore, expressions of the receptors on the surface and actin formation compared to young are also different. This review delves into the role of glia during aging and the development of the diseases. The susceptibility of different regions of the brain to disease are linked to the overstimulation of signals related to the immune system during aging, as well as the damaging impact of these cascades on the functionality of different populations of microglia present in each region of the brain. Furthermore, a decrease in microglial phagocytosis has been related to many diseases and also has been detected during aging. In this paper we also describe the role of glia in different illness, such as AD, ALS, pain related disorders, cancer, developmental disorders and the problems produced by opening of the blood brain barrier. Future studies will clarify many points planted by this review.
dc.language.iso	eng
dc.relation.ispartof	International Journal Of Medical Sciences, 2019, vol. 16, num. 11, p. 1473-1479
dc.title	Function of Glia in Aging and the Brain Diseases
dc.type	journal article	es_ES
dc.date.updated	2020-05-25T10:21:38Z
dc.identifier.doi	10.7150/ijms.37769
dc.identifier.idgrec	134787
dc.rights.accessRights	open access	es_ES