Podoconiosis is a non-infectious cause of lymphedema, frequent in Africa. The aim of this study is to implement the management of lymphedema secondary to podoconiosis in a rural hospital in Southern Ethiopia. A call for donation of compression garments was made in Spain, to give any used and retired garment among lymphedema patients. The working plan was to train the staff in the lymphatic system, the causes of lymphedema, prevention strategies, skin care, intensive treatment and maintenance at long-term, Decongestive lymphatic treatment of the patients affected from podoconiosis and the adaptation of the donated garments for maintenance phase. Fifteen patients were treated with 10 sessions of Decongestive Lymphatic Therapy (DLT) consisting of Manual Lymphatic Drainage and multilayer bandages. The Percentage of Volume Reduction was 11.3% (95%CI: 8.8-13.9). Fifty percent of the patients showed an increase of the volume of lymphedema as they did not comply with the compression treatment. This pilot study has had good results in helping lymphedema management in Southern Ethiopia. The donation of used garments by chronic patients can be a feasible and effective step to improving the maintenance phase of patients with lymphedema in places with limited resources.