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Histo-blood group antigens in children with symptomatic rotavirus infection

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Histo-blood group antigens in children with symptomatic rotavirus infection

dc.contributor.author	Pérez Ortín, Raúl
dc.contributor.author	Vila Vicent, Susana
dc.contributor.author	Carmona Vicente, Noelia
dc.contributor.author	Santiso Bellón, Cristina
dc.contributor.author	Rodríguez Díaz, Jesús
dc.contributor.author	Buesa Gómez, Javier
dc.date.accessioned	2020-06-09T11:07:35Z
dc.date.available	2020-06-09T11:07:35Z
dc.date.issued	2019
dc.identifier.citation	Pérez Ortín, Raúl Vila Vicent, Susana Carmona Vicente, Noelia Santiso Bellón, Cristina Rodríguez Díaz, Jesús Buesa Gómez, Javier 2019 Histo-blood group antigens in children with symptomatic rotavirus infection Viruses 11 339
dc.identifier.uri	https://hdl.handle.net/10550/74958
dc.description.abstract	Abstract: Group A rotaviruses are a major cause of acute gastroenteritis in children. The diversity and unequal geographical prevalence of rotavirus genotypes have been linked to histo-blood group antigens (HBGAs) in different human populations. In order to evaluate the role of HBGAs in rotavirus infections in our population, secretor status (FUT2+), ABO blood group and Lewis antigens were determined in children attended for rotavirus gastroenteritis in Valencia, Spain. During three consecutive years (2013-15), stool and saliva samples were collected from 133 children with rotavirus infection. Infecting viral genotypes and HBGAs were determined in patients and compared to a control group and data from blood donors. Rotavirus G9P[8] was the most prevalent strain (49.6%), followed by G1P[8] (20.3%) and G12P[8] (14.3%). Rotavirus infected predominantly secretor (99%) and Lewis b positive (91.7%) children. Blood group A and AB children were significantly more prone to rotavirus gastroenteritis than blood group O children. Our results confirm that a HBGA genetic background is linked to rotavirus P[8] susceptibility. Rotavirus P[8] symptomatic infection is manifestly more frequent in secretor-positive (FUT2+) than in non-secretor individuals, although no differences between rotavirus G genotypes were found.
dc.language.iso	eng
dc.relation.ispartof	Viruses, 2019, vol. 11, num. 339
dc.subject	Virus RNA
dc.subject	Gastroenterologia
dc.title	Histo-blood group antigens in children with symptomatic rotavirus infection
dc.type	journal article	es_ES
dc.date.updated	2020-06-09T11:07:35Z
dc.identifier.doi	10.3390/v11040339
dc.identifier.idgrec	131115
dc.rights.accessRights	open access	es_ES