NAGIOS: RODERIC FUNCIONANDO

Prevention of Rat Intestinal Injury with a Drug Combination of Melatonin and Misoprostol

Repositori DSpace/Manakin

Valencià Castellano

Inici
Investigació
e-prints
23 - Química
Visualitza element

IMPORTANT: Aquest repositori està en una versió antiga des del 3/12/2023. La nova instal.lació está en https://roderic.uv.es/

Prevention of Rat Intestinal Injury with a Drug Combination of Melatonin and Misoprostol

Mostra el registre parcial de l'element

dc.contributor.author	Dahlgren, David
dc.contributor.author	Cano Cebrián, María José
dc.contributor.author	Hellström, Per M.
dc.contributor.author	Wanders, Alkwin
dc.contributor.author	Sjöblom, Markus
dc.contributor.author	Lennernäs, Hans
dc.date.accessioned	2020-09-28T13:43:39Z
dc.date.available	2020-09-28T13:43:39Z
dc.date.issued	2020
dc.identifier.citation	Dahlgren, David Cano Cebrián, María José Hellström, Per M. Wanders, Alkwin Sjöblom, Markus Lennernäs, Hans 2020 Prevention of Rat Intestinal Injury with a Drug Combination of Melatonin and Misoprostol International Journal Of Molecular Sciences 21 6771
dc.identifier.uri	https://hdl.handle.net/10550/75669
dc.description.abstract	A healthy intestinal barrier prevents uptake of allergens and toxins, whereas intestinal permeability increases following chemotherapy and in many gastrointestinal and systemic diseases and disorders. Currently, there are no approved drugs that target and repair the intestinal epithelial barrier while there is a medical need for such treatment in gastrointestinal and related conditions. The objective of this single-pass intestinal perfusion study in rats was to investigate the preventive cytoprotective effect of three mucosal protective drugs¿melatonin, misoprostol, and teduglutide¿with different mechanisms of action on an acute jejunal injury induced by exposing the intestine for 15 min to the anionic surfactant, sodium dodecyl sulfate (SDS). The effect was evaluated by monitoring intestinal clearance of 51Cr-labeled ethylenediaminetetraacetate and intestinal histology before, during, and after luminal exposure to SDS. Our results showed that separate pharmacological pretreatments with luminal misoprostol and melatonin reduced acute SDS-induced intestinal injury by 47% and 58%, respectively, while their use in combination abolished this injury. This data supports further development of drug combinations for oral treatments of conditions and disorders related to a dysregulated or compromised mucosal epithelial barrier.
dc.language.iso	eng
dc.relation.ispartof	International Journal Of Molecular Sciences, 2020, vol. 21, num. 6771
dc.subject	Absorció intestinal
dc.subject	Farmacologia
dc.title	Prevention of Rat Intestinal Injury with a Drug Combination of Melatonin and Misoprostol
dc.type	journal article	es_ES
dc.date.updated	2020-09-28T13:43:39Z
dc.identifier.doi	10.3390/ijms21186771
dc.identifier.idgrec	140564
dc.rights.accessRights	open access	es_ES