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Enantioselective Synthesis of 5‑Trifluoromethyl-2-oxazolines under Dual Silver/Organocatalysis

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Enantioselective Synthesis of 5‑Trifluoromethyl-2-oxazolines under Dual Silver/Organocatalysis

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dc.contributor.author	Martínez-Pardo, Pablo
dc.contributor.author	Blay Llinares, Gonzalo
dc.contributor.author	Vila Descals, Carlos
dc.contributor.author	Sanz Marco, Amparo
dc.contributor.author	Muñoz, M. Carmen
dc.contributor.author	Pedro, José Ramón
dc.date.accessioned	2020-09-29T16:31:58Z
dc.date.available	2020-09-29T16:31:58Z
dc.date.issued	2019
dc.identifier.citation	Martínez-Pardo, Pablo Blay Llinares, Gonzalo Vila Descals, Carlos Sanz Marco, Amparo Muñoz, M. Carmen Pedro, José Ramón 2019 Enantioselective Synthesis of 5‑Trifluoromethyl-2-oxazolines under Dual Silver/Organocatalysis Journal of Organic Chemistry 84 314 325
dc.identifier.uri	https://hdl.handle.net/10550/75689
dc.description.abstract	The first enantioselective formal [3 + 2] cycloaddition between α-isocyanoesters and trifluoromethylketones to give 5-trifluoromethyl-2-oxazolines bearing two contiguous stereogenic centers, one of them being a quaternary stereocenter substituted with a CF3 group, has been developed. The reaction is based upon a multicatalytic approach that combines a bifunctional Brønsted base-squaramide organocatalyst and Ag+ as Lewis acid. The reaction could be achieved with a range of aryl and heteroaryl trifluoromethyl ketones, and the resulting oxazolines were obtained with good to excellent diastereo- and enantioselectivity.
dc.language.iso	eng
dc.relation.ispartof	Journal of Organic Chemistry, 2019, vol. 84, p. 314-325
dc.subject	Química orgànica
dc.subject	Catàlisi
dc.title	Enantioselective Synthesis of 5‑Trifluoromethyl-2-oxazolines under Dual Silver/Organocatalysis
dc.type	journal article	es_ES
dc.date.updated	2020-09-29T16:31:59Z
dc.identifier.doi	10.1021/acs.joc.8b02808
dc.identifier.idgrec	129211
dc.rights.accessRights	open access	es_ES